Some of you might be interested in molecules that chemists use to form
stable free radicals. It is remarkable how similar in structure some
of them are to polyphenols, which probably helps to explain some of
their properties. I would suspect that this kind of work underpins
much of the supplementation that we do today. Chemistry is not my
specialty, but I found this small collection to be very interesting,
and probably valuable to someone.
I am adding molecules links throughout the blog, which should be more
helpful to many readers who are researching supplements. It is
pleasing to see the interest that is developing around the blog, and
the molecules site
activism. For those who are interested in learning some more about me,
and why I am doing this, here is some reading. It is remarkable how an
old bio sometimes retains its life and meaning. Here is my first bio
on the web.
That one ends at Purdue. The links at the bottom of the bio can bring you up to date, and they are all listed in the links section of this blog
as well. BTW, I find it surprising how many members have not added any
links. I have looked at many of your links pages. If you add some,
please let me know. Providing backlinks from other sites will raise
the profile of your blog and promote our community. It will also help
us to better understand what brought you here.
A better summary of the latest bio information is perhaps found on the GNU-Darwin site.
activism was first launched as an adjunct to GNU-Darwin, but I would
not be surprised to see the subdomain eclipse GNU-Darwin some day. The
subdomain continues to grow in profile. Our plan will take years and
decades to complete, but the site is growing every day. Our next phase
to add more accurate 3D molecular representations is set to begin
soon. It is projected that Google will need a full year to crawl it
once the additional information is in place, and we are still only
getting started. It is projected that we will need new hardware not
long after that, and hopefully there will be funds for that.
That is all for now. Don't forget to tell me, if you add links to your blog.
many people, I am skeptical of information coming out of the US
government, but this info has strong consistency with information
obtained from other sources. Parsley, capers, and elderberry are a
knockout. Elderberries remind me that I need a little detour to add cyanidin to the cross-comparison.
for weight watchers, you can use info like this from the USDA to get
the most nutrution out of a small amount of food. Flavonoids often add a ton of flavor into a small amount of calories. The USDA also has a nice carotenoid database. Cheers!
This is another late night quick update on several items. I
managed to isolate the effects of the flax oil with lignan fraction
formulations, and I am checking off. I could not detect any
increase in blood pressure, or any decongestant effect either.
It is likely that this is a most healthful oil formulation, second only
to certain fish oils.
I think that the lignans add a little bitter taste to this oil, which
is comparable to some olive oils that may be similar, but I recommend
the flax oil anyway. Cooking and acidic foods are likely to create
something deeply pleasant from the bitters. In fact, I have a
recipe for this below.
Before proceeding to the recipe, I would like to point out a problem
with citrus bioflavonoids, like hesperidin and naringinin.
Although citrus fruits typically have hundreds of milligrams of these
beneficial substances, they are not absorbed well into the body.
In fact, the absorption is terrible, in spite of the high vitamin C
content of the fruit. One reason for this may be that people tend
to wolf citrus fruits down without chewing, and I recommend small,
well-chewed bites. I have also applied some biochemical insights
and kitchen wizardry to make a recipe that attempts to address this
Again, before proceeding to the recipe itself, I need to point out that
this citrus pudding has a very unusual ingredient, fresh ground
pepper. Like the flax oil bitters, this spice takes on a very
different and rich taste in the acidic pudding mixture. Here is
Juice two citrus fruits, and save the pulp. Set the juice aside,
or drink it as you like. It is not a part of the pudding.
The vast majority of healthful fiber and flavanoids are found in the
pulp. Be sure to juice vigorously all the way to the peel.
Put the pulp in a soup bowl, and add 1/2 teaspoon of vegetable
oil. I am recommending the flax oil because of the high omega
3 and lignan content. Add 1/2 teaspoon of fresh ground
pepper, and a large heaping tablespoon full of yogurt. Make sure
that you have the kind with live cultures, because this will aid in the
digestion of the fiber and absorption of the flavonoids. Like the
flax lignans, this is very healthful fiber, and it is helpful to find a
way to digest it. Stir the pudding to a thick uniform mixture,
then enjoy your delicious treat.
I recommend experimenting with more pepper. The combination of
citric acid and emulsion will remove any unpleasant taste, and like the
other ingredients, the pepper may aid in absorption of the citrus
bioflavanoids. Be sure and use fine ground fresh pepper.
If you have recommendations for this new recipe, be sure and post
them. I am anxious to try them. I am really enjoying my
citrus this way, and I promise a big wet kiss to anyone who can prove
that it does not improve the absorption of these crucial
nutrients. Enjoy your pudding. It is very filling and
I am following up with research on some of the foods on the list,
particularly the ones that I am less familiar with. So I started
with rutabagas, and this humble vegetable is taking far longer to
research than I expected, which mostly explains why I haven't posted
recently. There is rapeseed oil, canola, Monsanto,
turnip greens, and much much more; each with research
forks. It is really a marvellous subject, and there will likely
be more in the future about this, but that is unfortunately all that I
can say for now. I'll leave you with one of the more interesting
references that I turned up, related to autism and iodine. Cheers!
We are fortunately living in a time when the comparitive merit of the
various polyphenols is being studied, so that we can survey the
literature to find the best new supplements, and the best
combinations. The first round of my survey has returned the
following results. It supports my suggestion that one polyphenol
supplement is not enough, and it is recommended to take a panel of
them. This survey has its own bias as to time, because quercetin,
resveratrol, egcg, and curcumin have received the most study, whereas
hopeful prospects such as, silymarin, naringenin, apigenin, and
kaempferol are new to the game in the comparitive studies.
Curcumin consistently scores highly, although not always the
best. It is first mentioned, because it is rarely shown to have
adverse effects. egcg and resveratrol, though getting frequent
top scores, occasionally produce effects that are contrary to the
aim. Quercetin is the midling, although it may be better grouped
with curcumin. It is no surprise to see that curcumin, quercetin,
and egcg are as popular in the supplement community, or more so, than
resveratrol, due to the equally promising results that they have
produced. I recommend a minimum panel of these four polyphenols
taken together, each at their effective dose.
Other molecules that have received less attention, but score fairly
well are naringenin, silymarin, and apigenin. Fisetin and chrysin
dropped out in this round. I think that additional
supplementation with naringenin, silymarin, and apigenin is not a bad
idea. Other candidates will be coming to light in the
It should be noted that there are food sources which are often
sufficient to provide the necessary amounts of many of these substances
in order to produce the desired effect. These foods include
citrus fruits, red onions, rutabagas, kale, as well as certain berries,
grapes, and pomegranate. I would also recommend celery, thyme,
parsley, and green peppers. (personally, I like the red peppers ;-)
I am afraid I that it is late for me tonight. I am tired, so that I am
surely forgetting something, and there will certainly be further
followup. I was able to produce a few more caveats and
suggestions. I don't recommend more than 500 mg of egcg per day,
until it can be demonstrated that a panel of polyphenols will prevent
the resulting DNA strand breaks. This is an important concern,
because it is easy to get far more that 500 mg of egcg from widely
available supplements. The higher dose produces nPKC activation
in keratinocytes and the resulting free radicals are shuttled to the
nucleus by egcg. There is sure to be more about this type of
problem in the future.
I would also like to point out that these molecules can inhibit COX
enzymes and related systems, which is widely noted as a positive
benefit. Unfortunately, oversuppression of COX may lead to kidney
damage, due to the fact that the kidneys rely on prostaglandins for
vasodilation. As a result of this realization, I have been
monitoring my kidney function carefully using the chemistry panel
tests, and I can say that it is very unwise to overuse NSAIDS and other
COX inhibitors while on a polyphenol or flavanoid regimin. It is
unwise in any case, so please review your use of these analgesic
molecules, such as aspirin, ibuprofen, naproxen sodium etc. Check the directions
again. My doctor is recommending acetaminophen instead, but I suggest using well below the recommended acetaminophen dose, especially when used in combination with aspirin. The molecular mechanisms of these two compounds are related. Supplementing with a strictly low dose of aspirin is
probably still beneficial and possibly synergistic, as it were, with
the polyphenol regimen, but I recommend regular kidney panels to anyone
who is following the polyphenol or other CR-related regimens.
Relatedly, I have been experimenting with forskolin in order to provide
an offset of vasodilation. Forskolin likely provides many
healthful benefits in addition to this one, and it is probably not a
bad idea to take it with your aspirin, but maintain a strict
regimen. Use only small dose aspirin, and don't miss your
forskolin doses, or you will experience the rollercoaster effect.
You might also need an occasional dose of antacid with this
combination. It is fashionable to avoid aluminum in the antacid.
Here is a bit more regarding the specific health
concerns, with the supplements that score best in the respective
studies. The lists are mostly in order of effectiveness. I also lists the supplements that didn't work.
When it says "beats", this means that the supplement produced a
contrary result to the aim; it was adverse.
I hope that it is helpful to have the results summarized in this
way. Here are the references, so that you can check for yourself.
Optometry. 2009 Dec;80(12):695-701.
Molecular medicine in ophthalmic care.
Richer S, Stiles W, Thomas C.
Biochem Biophys Res Commun. 2005 Jul 22;333(1):21-7.
Resveratrol and curcumin reduce the respiratory burst of Chlamydia-primed THP-1 cells.
Deby-Dupont G, Mouithys-Mickalad A, Serteyn D, Lamy M, Deby C.
Pharmazie. 2002 Dec;57(12):852-4.
Protection against damaged DNA in the single cell by polyphenols.
Liu GA, Zheng RL.
Toxicol Sci. 2007 Apr;96(2):227-36. Epub 2006 Oct 31.
Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.
Ebert B, Seidel A, Lampen A.
Nutr Cancer. 2004;49(2):200-8.
Phytoestrogens in common herbs regulate prostate cancer cell growth in vitro.
Shenouda NS, Zhou C, Browning JD, Ansell PJ, Sakla MS, Lubahn DB, Macdonald RS.
Int J Cancer. 2000 Aug 15;87(4):595-600.
Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential.
Caltagirone S, Rossi C, Poggi A, Ranelletti FO, Natali PG, Brunetti M, Aiello FB, Piantelli M.
Nutr Res. 2009 Aug;29(8):568-78.
Select phytochemicals suppress human T-lymphocytes and mouse
splenocytes suggesting their use in autoimmunity and transplantation.
Hushmendy S, Jayakumar L, Hahn AB, Bhoiwala D, Bhoiwala DL, Crawford DR.
Free Radic Biol Med. 2007 Feb 1;42(3):315-25. Epub 2006 Oct 11.
Modulation of pregnane X receptor- and electrophile responsive
element-mediated gene expression by dietary polyphenolic compounds.
Kluth D, Banning A, Paur I, Blomhoff R, Brigelius-Floh<E9> R.
Pharmacol Res. 2006 Feb;53(2):113-22. Epub 2005 Oct 21.
Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways.
Wung BS, Hsu MC, Wu CC, Hsieh CW.
Mutat Res. 2003 Feb-Mar;523-524:163-72.
Mechanism-based in vitro screening of potential cancer chemopreventive agents.
Gerh<E4>user C, Klimo K, Heiss E, Neumann I, Gamal-Eldeen A, Knauft J, Liu GY, Sitthimonchai S, Frank N.
"EGCG and EG partially suppressed catalase activity."
Biol Pharm Bull. 2007 Feb;30(2):213-7.
Chemical structure-dependent differential effects of flavonoids on the
catalase activity as evaluated by a chemiluminescent method.
Doronicheva N, Yasui H, Sakurai H.
Arch Pharm Res. 2005 Nov;28(11):1293-301.
Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro.
Lyu SY, Rhim JY, Park WB.
Mutat Res. 2000 Apr 28;459(3):211-8.
Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA.
Johnson MK, Loo G.
I would like to share my intitial impressions regarding tyrosol and
lignins. I finally got a chance to try a couple of products
containing these substances, and I was able to do a little checking,
including some blood pressure measurements. I am borderline
prehypertensive for various reasons, many of which are harmless, but I
like to keep an eye on it. It should be noted that these
impressions are preliminary, empirical, and anecdotal.
Lignins are a highly varied and often complex molecular species, so that it should always
be inquired as to what type of lignans are being referred to. I
am convinced that lignan molecules can be expected to be at the
frontier of longevity medicine. It is no surprise that there is
much excitement around these compounds, which have good free radical
quenching capabilities, and similar structures to other polyphenolic
compounds, which have been demonstrated to have enormously healthful
Tyrosol is another molecule which shares in the same interesting
properties as lignans in the general sense, and in fact, many lignans
are based on tyrosol. These include the lignins in flax and
olive. Tyrosol has been demonstrated to have similar beneficial
qualities, but it is also deserving of certain caveats, as are the
tyrosol lignan class in general.
Tyrosol and tyrosol lignans are included in certain nasal and throat
spray preparations, and it is not surprising that they exhibit a
decongestant-like property, due to their similar structure to adenergic
molecules, such as norepinephrine. In fact, tyrosol has been
demonstrated to have antiarrhythmic effects, which could be beneficial
for some people. This is consistent with alpha-1 adenergic
activation, and explains the decongestant effect as well.
At this juncture, I would like to remind that these are preliminary
findings, and people should search out the matter in the literature for
themselves. My research is indicating at this time that alpha-1
activation is not beneficial from a longevity perspective, and is
likely to cause harm to people with rapid heartbeat or high blood
pressure. One reason for this is the resulting Akt activation,
which you can look up for yourself. I try to avoid alpha-1
activation, which is a stress
response. For this reason, I have until now tried to avoid
decongestant medicines, which are typically alpha-1 adenergics.
Tyrosol shares its molecular properties with norepinephrin, the body's
native alpha-1 receptor ligand, and as such it can be expected that
there are ameliorating factors which offset the problems. Although, alpha-1
activation may lead to runaway calcium cascades, tyrosine kinase
activation, and an increase in inflammatory factors, these effects
which are often adverse are offset by the phenolic structure of the
molecule, which may tend to scavange the resulting free radicals and
produce some of the other benefits that are associated with
polyphenols, like resveratrol.
My advice at this time is to use discretion and moderation when
supplementing with tyrosol and tyrosol lignins. Consider the
state of your health. Personally, with borderline
prehypertension, I will tend to use less than some other people. For
example, I will use the topical and intranasal preparations only as needed.
I have the flax oil with lignan fraction preparation from NSI, and I
it could be beneficial, but due to these concerns, I will limit myself
occasional 1/2 teaspoon. I like it in my yogurt fruit
smoothie, and it tastes better than olive oil in the juice. Much
more could obviously be said about olive oils. Anyway, for people
with low blood pressure and/or adverse
congestion and swelling in the nasal epithelium, the effects may be
Adenergics are frequently a part of body building regimens, and I would
advice caution. There are beta-adenergic agonists, which are
probably more on target and effective than the alpha-1 agonists.
Moreover, they can be expected to be more heathful in the general sense
I am afraid that I am always eager to try the hottest new supplement,
in order to expand my longevity program, and as a result, I do not
always proceed with scientific rigor. I find myself backpedalling
from time to time, which is why I put the caveats on this piece.
I must confess that the observed effects could be due to a change in my
vitamin E regimen, but I find that unlikely.
For the future, I think that tannins are in a similar preliminary state
as lignins. There are huge potential benefits, but an equal
degree of concerns. I hope that this information helps someone, and I will post updates as I learn more.
Incidentally, for those concerned about high blood pressure, you might
want to have a look at forskolin. It is available in herbal
extract form from NSI. I recommend a strict regimen when
using forskolin, in order to avoid the rollercoaster effect. It
would probably be wise to consult with a healthcare professional about
it. I will probably have more to say about this later, as it is
related to this story above.
Finally, I would like to boost another new idea. I think
that phenolics which are not alpha-1 adenergic would be a better
addition to an intranasal spray. It would not give users that
familiar punch, but it would be more benefical in the long run.
There are many naturally occuring flavonoids, which are known to have
beneficial antimicrobal activity, and it should not be difficult to
find the best one, perhaps among the citrus variety. In a
suspension with a little citric acid to lower the pH and aid
absorption, it could be quite beneficial and effective, without the
alpha-1 body load... BTW, for the throat spray too.
I have automated the process to make molecule galleries, which I am
finding very useful to my research, so I thought that I would share the
opportunity and take requests. It is quick and easy. For example, I did a bisphenol
search, and as I expected, the search turned up a few stilbenes,
which is the same molecular family as
resveratrol. Here is a link
to one of our
Suprisingly, it also
turned up some
DDT-like molecules, which possibly
indicates the care which must be exercised when using this class of molecules.
Bisphenol A is a noted teratogen, which demonstrates the caution which must be exercised
when using such molecules during pregnancy, nursing, and development. Here is a link to the
If you would find it useful, I am definitely interested in
requests for molecule galleries. Be sure to check in the search
box and mod directory, because we already have thousands of galleries,
and thousands more are in the pipe now. Anyway, just send me the name
As you may be able to tell, we have access for
galleries to about 1% or 0.5 million structures, in the total archive
thus far, but it is already quite useful. The automated jobs are
underway to fill in the rest. The next milestone is the capability to
index and make galleries for the remaining millions of molecules for
which we have pdb files already, which would be 5-10% complete. As always,
comments or suggestions are certainly welcome, and please feel free to pass along this info as you like.
Michael L. Love Ph.D
Department of Biophysics and Biophysical Chemistry
School of Medicine
Johns Hopkins University
725 N. Wolfe Street
Room 608B WBSB
Baltimore MD 21205-2185
Happy New Year! Great things come in small packages! Do you
remember the one with 10,000 terabytes of storage in the size of an
acorn? Great things, like babies, and dream houses, and caviar;
not to mention a small box of great supplements. Small things
great. At this time of year may we all remember the small things
which bring great blessings to our lives. Memories, and the
precious centimeters between our ears. Let's be thankful and take
care of our precious things. May we all have many more of them in
the coming year!
I thought that the Vitacost community might be interested in the latest
snippet from the Molecules site news, featuring Vitacost and
For those who are following the activism aspect of the Molecules site, I thought that you might
be interested in a little pre-history as it were. Prior to the founding of the Molecules site,
the activism first hatched under the GNU-Darwin umbrella, and the fundamental idea of molecules
activism was invented. Initially, it was concerned primarily
with resveratrol and other caloric restriction memetics, but it was clearly bound to expand
from there. You can read some of the early material in the
GNU-Darwin Posts regarding resveratrol and calorie restriction.
As was previously mentioned, the ideas were formally developed in the
FOSS, Science, and Public activism
essay, and it was even put forth as a war protest in the so-called
As the Molecules site developed, it became clear that additional adjunct activities
were required in order to push the activism harder. One of these adjuncts was created on the Vitacost
website, where it is
easy to provide directed links
to crucial molecules for those who want to
obtain them for themselves. Moreover, the activism ideas continue to evolve there in blog format. Check it out:
Michael L. Love proclus Blog on Vitacost.
Tonight I found some very satisfying news related to all of this.
One of the last few GNU-Darwin posts regarding resveratrol and
caloric restriction referred to the very high anthocyanin content
of the forbidden Thai black rice. You can read about that in the
link above. At the time that I wrote the post there was virtually
no product development around the black rice, but now I am happy to
learn that there are many such products. Several can be found on
the Vitacost website. Obviously, I cannot take any credit for
this marvellous development, but the success is consistent with the
activism ideas that I have been developing. There are many
examples of such successes, some of them are documented in a free software activism article that I wrote several years ago. The implications are pretty far reaching. For more examples, check out this page on GNU-Darwin, or the links page and personal page
of this blog. We also should consider the possibility that
thinking in similar veins together makes great minds out of us.
Of course the internet itself seems pre-designed for that sort of
Hopefully this post will be Merry Christmas to someone. I am
surprised by how hard it is to find antifungal nasal spray, as it is
likely to address many health complaints. Thus far, I am not
impressed with the herbal remedies that purport to do this, although I
am willing to listen to any credible evidence. A big problem with
some of the remedies is likely that they are not strong enough.
The spray should be strong enough to wipe out all fungal colonies in
the nasal cavities, and it should also probably have antibacterial
properties to prevent opportunistic infection. This will make the
preparation very strong, and it is likely to cause some nasal
dryness. Not to worry, because that will be a relief to most
As for the health complaints, it is likely a very widespread problem,
due to piggy backing on skin, mite, and insect particles, as well as
the airborn spores, which are likely to lodge in the nasal
cavities. Even overeating could cause the problem, due to
nocturnal regurgitation. Personally, I live in an old red brick
house in an urban setting near the sea. The old brick draws
out moisture from the surrounding soil and air, and is likely furtile
ground itself. Such conditions provide ample opportunity for the
growth of mold and fungus, and I actually found overnight mushroom
heads in my bathroom on a couple of occasions. (BTW, I keep a
clean house, and follow the cleanup rules for allergy and
asthma.). I have chronic post nasal drip and atopic cough.
When I eat food , such as citrus fruits or red onions, with anti-fungal
properties, my throat feels better immediately. Unfortunately, I
can't stick tangerines up my nose ;-}, and with the post nasal drip,
the condition returns. I am waiting for someone to capitalize on
this good idea. I gladly will be your trusting guinea pig.
There are a few problems. I can make it update periodially
with a cron job, so I would need a suggestion regarding the
interval. Also, the links in the Health Daily items are broken,
probably due to a shortcoming in my email extraction code.
I am now tired and abit clueless about how to fix them at this
moment. Hopefully I am not stepping on any toes ;-}.
Anywho, enjoy! Cheers!
I am expecting that the following polyphenols will be both highly
effective and good free radical scanvengers as well. This is not
based on any scientific evaluation, but rather on their widespread use
and interest. People are not dummies. Work continues.
Here is the list in order of priortity.
There is a
wide range represented in the list, and right away I notice that lutein
probably does not deserve such high placement in comparison to the
others. There are some other possible misplacements, and
biochemical insights will provide some refinements of the
list. I cut the list very deep in order to include the
citrus bioflavanoids, and it probably includes some less important
molecules as a result. For example, I mentioned chrysin in a
previous post as a possible problem, and rutin probably does not belong
above egcg. More to come.
You can probably get a good approximation of this list by checking the Vitacost best sellers. Try searching on antioxidant. It is such a wonderful website, which helped me to compile this list and develop my program. Cheers!
I grabbed the following information from my Amazon Seafood Wishlist, because I thought that it deserved more visibiltiy.
healthful benefits of seafood are widely noted. I am searching
for seafood which is low in mercury, high in DHA, and high in
astaxanthin, and found that red salmon fills the bill.
one of the beneficial unsaturated omega 3 fatty acids, which is already
widely known for its healthful benefits, and sure to be rising in
prominence as well. Caviar is probably one of the best sources of
DHA, far and away, and the red variety is also likely rich in
astaxanthin, while the black variety is rich in melanin compounds,
which are also likely to be healthful. One must be wary however
of the food colorings that are used to produce the color in less
expensive caviar. Due caution, and more information is
needed. I have written an Amazon Guide
about this. I am looking for inexpensive caviar that is also low
in food coloring. See the wishlist for some examples. There
are additional notes about some of the inexpensive caviars in the
images section. I am projecting that the simple unprocessed
salmon roe will be the best.
Astaxanthin is a
carotene-like nutrient that is only available from red fish and certain
shell fishes, such as shrimp. I have been told that shrimp are
fed to fish in order to deepen their beneficial redness.
salt is a problem with seafood, but the benefits probably outweigh this
problem, especially if you eliminate salt from other parts of your
diet. Sodium is a particular problem for caviar, and it is
probably unwise to eat unrinsed caviar. Better than rinsing,
desalt the caviar. The eggs desalt rapidly because of their small
size, and it improves the taste considerably. Don't use too much
water though, because it will leach out the DHA. Just add enough
water to cover over the eggs, stir gently to break up the clumps, let
stand for a few minutes, then drain and rinse. Enjoy your caviar
One more thing for Weight Loss Vitacosters, I have
found that substituting red salmon and citrus fruits for calorie dense
foods has reduced my hunger pangs considerably. Clearly, the
salmon can be expected to be very satisfying. I have lost several
pounds as a result of this change. I restrict the salmon to a
heaping tablespoonful per meal, twice per day, which still provides a
substantial amount of the mentioned nutrients.
I would like te share a little regarding the current direction of my
research. The subject may be familiar to most avid users of the
Vitacost website. There is a problem with some of the phenolics
in that they are
surprisingly not good free radical quenchers, and may in fact spread
free radical damages, if not worsen it. This needs to be better understood.
The importance of this subject becomes evident in consideration of
their binding near the reacting centers of COX enzymes, various
oxidases, and perioxidases. They are thus sequestered near centers of
free radical activity, and their ability to quench that activity is known to be a
crucial component of their functionality.
Chrysin is a flavanoid that is known to have relatively poor free radical quenching
activity, although it is able to bind and inhibit similar targets as
other polyphenols. Due to this fact, chrysin is less effective at
producing some of the key benefits of this class of molecules, and it
may actually aggravate the damage caused by enzymes like
myeloperoxidase. It is
known that there are other examples of this phenomena, and a survey of
the literature is indicated. Here is my research list. I
have thrown in a few "errors", such as tomatoes and indoles for
comparison and cross-checking purposes. Images of these molecules are available for your inspection on the Molecules site. Just put them names in the search box. There is much more to
say, but perhaps some discussion is in order.
A Google search on 'molecules activism'
produces a page with Linus Pauling near the top. We are obviously
in good company. The expired Nobel chemist makes a great example
of an activist scientist, one that I have frequently admired. I
got a chance to see him speak once, when I was at Phoenix College, and
I was no less impressed. In truth, I have tried to emulate him in
many ways. His crucial contributions to the world of chemistry
and science in general are great enough, but he also drew much needed
attention to the problems that society faced in his day. If only
we could have more like him.
Also germane is the fact that he is
a main reason why many of us are taking vitamin C, something which he
continuously advocated. C is now indispensable for its ability to
increase the absorbency of polyphenolic molecules, such as resveratrol. For those of us who are attempting to practice calorie restriction, C supplementation is a vital part of the program. Hats off to Linus Pauling!
Regards, Michael L. Love Ph.D Department of Biophysics and Biophysical Chemistry School of Medicine Johns Hopkins University 725 N. Wolfe Street Room 608B WBSB Baltimore MD 21205-2185
Interoffice Mail: 608B WBSB, SoM Shipping Dock: 1915 E. Madison St.
My program is under constant development, and sites like Vitacost and Molecules
are excellent tools for program development. I have included a
few suggestions in my product recommendations section. Here is a
link to my personal page, where you will find my supplement
recommendations and product links.
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