Michael L. Love's blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: My brother's blog: Certain Conditions

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Posted Friday, Mar 26, 2010 1:16 PM by proclus | 1 Comments

My brother's blog: Certain Conditions

Hummingbird Sips a Golden Barrel Cactus

I took this picture with my HTC phone. I was a little surprised how well the wings were captured. Lucky shot!

via certain-conditions.com

Clearly worth a look.

Regards,
proclus
http://www.gnu-darwin.org/

Posted Thursday, Mar 25, 2010 6:13 PM by proclus | 0 Comments

Michael L. Love: Thank you SourceForge and many others too!

Many thanks to the SourceForge site, without which there would likely be no GNU-Darwin at all. Here is a link to the old GNU-Darwin site on SourceForge, now improved with additional links to the people and organizations who helped us grow. Many thanks to them all.

http://gnu-darwin.sourceforge.net/

Things should be returning to a more normal pace soon. It is getting late, and I must go stir my spaghetti pot. I am sure that I will have a bowl, which will push me to a 1 1/2 cups of parsley today. I think that parsley might be making me smarter too.

I must say that I feel similar gratitude to the Vitacost site as for the SourceForge. It is wonderful to have a blog on this site, where I can link and point people to the supplements that I use. If you haven't looked at my profile page, perhaps you should, because that is where you will find that information.

Michael L. Love: proclus blog Vitacost Profile Page
http://community.vitacost.com/Templates/MyPage.aspx?UserID=4424

I am following Vitacost on Twitter, which does not seem like a bad idea either.

http://twitter.com/Vitacost

Regards,
proclus
http://www.gnu-darwin.org/

The blog

GNU-Darwin Foundations

Michael L. Love: On value and money, molecules activism

Michael L. Love: Foundations

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Posted Saturday, Mar 20, 2010 8:13 PM by proclus | 0 Comments

These crucial foundational links are critically important from a historical perspective, for everything that flowed from my CHESS/MacCHESS Cornell University days, especially The GNU-Darwin Distribution. None of it would have happened, if I did not have access to these marvelous resources. This fact cannot be overstated.

http://gnu-darwin.sourceforge.net/gdc/mol.html
http://proclus.tripod.com/home.html
http://proclus.tripod.com/darwin/
http://gnu-darwin.sourceforge.net/tools_not_toys.html
http://proclus.tripod.com/

It is probable that this work led directly to my employment at Johns Hopkins University. Here is a link to my lab and current CV at Hopkins, where I am the X-ray Lab Manager. The foremost fact is that I like it there.

http://biophysics.med.jhmi.edu/love
http://biophysics.med.jhmi.edu/love/thesis/cv6.html

We have certainly come a long ways, but the best is yet to come.

Regards,
proclus
http://www.gnu-darwin.org/

Posted Wednesday, Mar 17, 2010 11:28 PM by proclus | 0 Comments

Michael L. Love: Facebook censors GNU-Darwin founder?

From: proclus@gnu-darwin.org

Subject: WRT facebook

Date: Tue, 16 Mar 2010 15:24:41 -0400 (EDT)

My public search listing is not public, even though I have followed the instructions to make it public, which I found here.

http://www.facebook.com/help/?ref=pf#!
/help/?search=public%20search%20listing

Anyone smell a rat? At any rate, these instructions are obviously faulty.

Regards,
proclus
http://www.gnu-darwin.org/

--
Michael L. Love Ph.D
Department of Biophysics and Biophysical Chemistry School of Medicine
Johns Hopkins University
725 N. Wolfe Street
Room 608B WBSB
Baltimore MD 21205-2185

Interoffice Mail: 608B WBSB, SoM

office: 410-614-2267
lab: 410-614-3179
fax: 410-502-6910
cell: 443-824-3451
http://www.gnu-darwin.org/

Visit proclus realm! http://proclus.tripod.com/ -----BEGIN GEEK CODE BLOCK-----
Version: 3.1
GMU/S d+@ s: a+ C++++ UBULI++++$ P+ L+++(++++) E--- W++ N- !o K- w--- !O M++@ V-- PS+++ PE Y+ PGP-- t+++(+) 5+++ X+ R tv-(--)@ b !DI D- G e++++ h--- r+++ y++++
------END GEEK CODE BLOCK------

The blog

Michael L. Love: On value and money, molecules activism

Michael L. Love: Three Years of Free Software Activism: The Case of GNU-Darwin OS

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Posted Tuesday, Mar 16, 2010 3:19 PM by proclus | 0 Comments

I am still quite busy with my daughter's visit, and in the meantime, I thought that readers might enjoy some additional background material.

More crucial background reading for the molecules activism aspect of the Molecule site and this blog, certainly exists. One such example, which continues as an important treatment of GNU-Darwin-style free software and political activism, is Three Years of Free Software Activism: The Case of GNU-Darwin OS. Although this article was written several years ago, it continues fresh, and the ideas formulated in the article are the bedrock of molecules activism.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: On value and money, molecules activism

Michael L. Love: I am 50 today, HOORAY!

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Posted Saturday, Mar 13, 2010 8:56 PM by proclus | 1 Comments

I am very happy to say that I am 50 years old today. I have had many great experiences in my life, and I am looking forward to many more. Here is to the next 50 years, and wish me luck on that one.

I have not blogged much lately, because I have been very busy with some behind the scenes work, as well as the fact that my daughter is in town for a visit. I had a happy birthday.

Regards,
proclus
http://www.gnu-darwin.org/

Posted Wednesday, Mar 10, 2010 8:09 PM by proclus | 4 Comments

Michael L. Love: blogging, facebook, and Radical Mormon

http://twitter.com/gnudarwin

Enjoy!

Michael L. Love

gnudarwin

gnudarwin Michael L. Love: Parsley recipe http://ping.fm/fLyfq 3 hours ago reply

gnudarwin Some bio info, blog links, plus some molecules site news http://ping.fm/eAfKe 3 hours ago reply

gnudarwin Michael L. Love: parsley and allergies http://ping.fm/Ceh2T 3 hours ago reply

gnudarwin Michael L. Love: recipe; flax oil, tyrosol lignans update http://ping.fm/yL7NZ 3 hours ago reply

gnudarwin GNU-Darwin Historical Review http://ping.fm/M9Reb http://ping.fm/adLBj http://ping.fm/i2l1T http://ping.fm/ygwCB http://ping.fm/zp0nT 14 hours ago reply

gnudarwin proclus-gnu-darwin's posterous - Michael L. Love/proclus/gnu-darwin posterous feed - sync... http://zooloo.com/l/6Fht 14 hours ago reply

gnudarwin http://ping.fm/bb9ff sync finished. This one brought back memories. Checkout GNU-Darwin historical in project blog. http://ping.fm/tOh8k 14 hours ago reply

gnudarwin @nicdarwin Nice start! The project needs to fix download links on the home page. We can discuss further, if you like. My french is bad tho yesterday reply

gnudarwin Twitter, MySpace, redirection and short URLS: http://slashdot.org/subm... 2 days ago reply

gnudarwin GNU-Darwin Action: Twitter, MySpace, redirection and short URLS http://ping.fm/7dqkA 2 days ago reply

Join the conversation

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: blogging, facebook, and Radical Mormon

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Posted Wednesday, Mar 3, 2010 5:53 PM by proclus | 0 Comments

It is pleasant to have this community website, which helps to keep me focused on my main life goals. I love these goals, but I must admit that I am not always a faithful lover. Moreover, I sometimes think that it is a little strange that I have started a blog and joined Facebook. Prior to starting this blog, I was using the Molecules site and my personal site on GNU-Darwin for publishing health and supplement related items. In fact, I have ample venues and means for pubishing my thoughts on the web. Here is an example, which goes way back. When Yahoo was nothing more than a page of links, I started The Radical Mormon and Mutant RM's. The web was still relatively small, and I included them with my conventional home page materials, which probably go back to 1996 or so. Prior to the web that we know, my software was on the ftp and gopher sites, from about 1990. Together, these were a significant addition to the total content at the time. These sites started many friendships. At the link below, you will also find links to all of my web publishing projects over the years.

Michael L. Love Ph.D

The Radical Mormon was founded in 1999 by Michael L. Love for and on behalf of the mutantRM's group, and it was the outer organ for this group for some time. The ideas expressed in this publication did not come out of nowhere, and they were hatched and sprouted in discussions within the mutantRM's group, and as well, the foundations were laid decades before. There are many many people to thank, and some of them are mentioned in the FAQ. As for the editor, Michael has been publishing on the web with great enthusiasm since 1998, and there is a...
Radical Mormon editor and contributors

Regards,
proclus
http://www.gnu-darwin.org/

Posted Sunday, Feb 28, 2010 2:40 PM by proclus | 0 Comments

Michael L. Love: blogging, facebook, and Radical Mormon

I have been busy writing. Some of it may appear here eventually. It is unclear to me that community members are interested in broader personal information, other than that which is focused on one of the four main interest categories. And I am inclined at this time to put such information elsewhere. Such is the case with the article I wrote today.

Google, user interests, and biasing factors
http://proclus.gnu-darwin.org/google-bias.html

Data from the community blog post tables assisted my conclusions. That is how I spent my morning. There is more in the pipe, such as some autobiographical information. I am currently thinking that community members are less interested in topics that do not fall strictly under the four goal/interest categories. Which is the main reason I have been posting such material elsewhere. I think that this article is germane to anyone who wants to promote their blog, which many in the community might find helpful. It is like the code I developed for blog extraction, and I am posting to all four groups because of this fact.

I split my bicycle rim this week, and I will likely spend the afternoon spoking it out. This problem is due to the magnesium, which is much softer than conventional bicycle materials. Other bicycles would be less expensive, more reliable, and stronger, as I describe in the winter bicycling articles. This is the disadvantage of riding in style, but I think that the advantages outweigh the disadvantages. The light weight and attention-getting appearance are the main advantages of this ultra-light bicycle. The crucial action is that people see the bicyclist. In addition to promoting the sport, it is good for the continued health and well being of the rider, as well as the writer.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Follow Michael L. Love:
on Google Buzz

Posted Saturday, Feb 27, 2010 2:27 PM by proclus | 0 Comments

Apr 2, 2010 10:37:55 AM

Michael L. Love: proclus molecules blog

Michael L. Love: blogging, facebook, and Radical Mormon

I have been busy writing. Some of it may appear here eventually. It is unclear to me that community members are interested in broader personal information, other than that which is focused on one of the four main interest categories. And I am inclined at this time to put such information elsewhere. Such is the case with the article I wrote today.

Google, user interests, and biasing factors
http://proclus.gnu-darwin.org/google-bias.html

Data from the community blog post tables assisted my conclusions. That is how I spent my morning. There is more in the pipe, such as some autobiographical information. I am currently thinking that community members are less interested in topics that do not fall strictly under the four goal/interest categories. Which is the main reason I have been posting such material elsewhere. I think that this article is germane to anyone who wants to promote their blog, which many in the community might find helpful. It is like the code I developed for blog extraction, and I am posting to all four groups because of this fact.

I split my bicycle rim this week, and I will likely spend the afternoon spoking it out. This problem is due to the magnesium, which is much softer than conventional bicycle materials. Other bicycles would be less expensive, more reliable, and stronger, as I describe in the winter bicycling articles. This is the disadvantage of riding in style, but I think that the advantages outweigh the disadvantages. The light weight and attention-getting appearance are the main advantages of this ultra-light bicycle. The crucial action is that people see the bicyclist. In addition to promoting the sport, it is good for the continued health and well being of the rider, as well as the writer.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

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on Google Buzz

Posted Saturday, Feb 27, 2010 2:27 PM by proclus | 0 Comments

Michael L. Love: On value and money, molecules activism

Just a short update tonight, as I am busy with a red hot GNU-Darwin Action. I had noticeably more tears today, and less stomach complaints in spite of eating a big pizza with very many red hot pepper flakes last night. Hopefully the trend will continue. Meanwhile, these are good indicators that I will be able to take a second thing off of my list, thanks to the parsley apigenin. I am still looking for more to take off of the list, although I intend to stay with the flavonoid panel. From a biochemical perspective, I am likely getting the benefits of both low and high dose flavonoids.

Regards,
proclus
http://www.gnu-darwin.org/

Posted Wednesday, Feb 24, 2010 7:42 PM by proclus | 0 Comments

Molecules activism could be viewed as the promotion of uncommon knowledge of commonplace things. The aspirin, the parsley, citrus fruits, all of which are commonplace things, readily in view and at hand. They all have little known properties which are highly valuable, although perhaps not in the shallow sense of monetary value. Common nuts, roots, and berries, which are sometimes valued little above the dirt that they sprout from, have unknown riches inside of them, not necessarily monetary wealth, but richness of health and strength. Such power is clearly not beyond our grasp, but it is merely unknown to us. We must establish such knowledge.

Table salt is a much derided molecule, but it has been indispensible for its ability to preserve food, a little known property perhaps. The economic impact may be small and ambiguous, but it has arguably saved countless of the lives of our very forebearers. That is wealth that transcends money. Similar things could be said about other commonplace minerals and chemicals. such as; bleach, lime, and even oxygen, all of which have many important uses beyond the commonplace ones, and properties beyond those which are commonly known.

Similar things could also be said of many ordinary spices; cinnamon, dill seeds, fennel, thyme, and common vegetables, such as tomatoes, and olives, as well as fruits, such as grapes. Many of these have preservative properties, but also they preserve life itself or increase our intellectual faculties, a vast and extraordinary richness indeed, beside which money is worth very little!

Some will brush this argument aside saying that everything I have referred to costs money, and sufficient money will get you any of it. Although this is a commonplace sentiment, it is also widely recognized as a foolish one. Moreover, such arguments are made by people who would like to diminuate the value of our very lives, which is rightly a subject of much outrage. I say that money cannot possibly be compared in value to things like life, intelligence, and posterity.

It is clear that there are riches unbeknownst to us at our very fingertips, and ever before our eyes. It also becomes obvious that the withholding of such knowledge is akin to a crime, and there are those of us in the movement who believe that the release of such knowledge should be MANDATORY. At least, those of us who are engaged in molecules activism will be doing our part to make such knowledge public, by the establishment of prior art, by publishing such knowledge, and by affixing it to the public common. Examples are many and growing, and they include this blog and the Molecules site. We will be generating more and more.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: blogging, facebook, and Radical Mormon

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Follow Michael L. Love:
on Google Buzz

Posted Tuesday, Feb 23, 2010 12:07 PM by proclus | 0 Comments

Now that I have been high dosing flavonoids for a few weeks, I think that it may be time for another change. My stomach acid and digestion have apparently returned to what they were before I started, and I definitely still need my proton pump blocker. I have a hypothesis about this, which is difficult to confirm. It is known that NSAID drugs like aspirin reduce chloride conductance of the CFTR channel. This is due to the reduction of prostaglandins, which in turn are not present in sufficient quantity to produce cAMP and activate the channel. Aspirin users may initially have a reduction of stomach acid due to this fact, but it is well known that the stomach may become irritated and even ulcerated in due course. One reason for this lies in the fact that NSAIDS reduce CFTR gene expression, probably due to reduced genetic activation via prostaglandin receptors, known as PPAR's. With the prostaglandin receptors under-stimulated, due to the presence of the NSAID, insufficient CFTR is made by the cell. This leads to the now famous erosion of the mucosal lining of the stomach. This much is known.

Hypothetically, it is likely that high doses of flavonoids, and other polyphenols such as resveratrol, will produce the same effect as the aspirin and other NSAIDS, because of similar inhibition of prostaglandin synthesis. Stimulation of cAMP production or CFTR activation would be insufficient to correct this protracted problem, because there would simply be not enough CFTR for sufficient mucous production to protect the lining of the stomach.

As I have previously noted, my eyes are also still just a little dry, so that I have two different phenomena to cross check the effect of an aspirin hiatus. It may be one of those cases of too much of a good thing, or in other words; the combination of high flavonoids and aspirin, like the anti-histamine, is simply too strong. It should take at least several days for CFTR expression to recover and I hope to have more tears and reduced stomach complaints again in a week or two. Maybe I can get off the Nexium after all. It will likely be no surprise to other users of proton pump blockers, that I have a third metric as well, that queasy acid alkaseltzer headache and nauseous feeling, which I expect to go as well. Thankfully, this problem has also been mild in its manifestation. It is best to take care of these things before they become a serious problem. Wish me luck.

If this hypothesis is true, then it is another case of the marvelous property of polyphenols to double up on their effects. For example, they inhibit COX and reduce COX expression. Likewise, they may block both CFTR channel activity and expression as well. It would be a profound effect and observation, because these type of double effects explain the refractory nature of CR-related regimens. As it has been noted, one continues to have the benefits of the regimen for at least several days after stopping. Cells have switches that are difficult to toggle back to their previous position, as it were, once they have been flipped. In this case, it is a forgiving regimen.

Having said that, it should be noted that aspirin hiatus may be dangerous for people who have been prescribed aspirin by their doctor. As the coxib fiasco has demonstrated, too much of a good thing can be catastrophic, so that people who are vulnerable to these types of problems should exercise caution with flavonoid regimens as well, especially in the high dose range.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

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Posted Monday, Feb 22, 2010 4:57 PM by proclus | 0 Comments

I have added some refinements to my citrus pudding recipe, so that it is now a tastey classic pudding, which can be used as a pie stuffer, or even baked into a pleasant loaf. It includes my trademark 1/2 cup parsley.

1/2 cup parsley flakes
1 medium to large citrus fruit
1 heaping teaspoon flax powder or nopalina
1 teaspoon cinnamon
1/2 teaspoon flax or olive oil
1/2 teaspoon fresh ground pepper.
2 tablespoons berry juice concentrate
1 large heaping tablespoonful of plain yogurt
1 large heaping tablespoonful peanut butter, or a small handful of nuts
1 bilberry teabag
1 Pau D'arco teabag

Mash ingredients together until well mixed. For pudding, microwave for 5.5 minutes on high. For bread, cook longer. Try mashing in some fresh fruit too, such as 1/2 of black grapes. Add a teaspoon of agave nectar, if you want it sweeter, but the mild tart flavor is pleasant and important for quenching the black pepper, which is a crucial part of the nutrient absorption regimen. This is definitely a citrus pudding, so don't substitute out the citrus.

I really enjoy getting my citrus and parsley this way on the weekends and snow days. Hope that you do too!

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Follow Michael L. Love:
on Google Buzz

Posted Sunday, Feb 21, 2010 8:36 AM by proclus | 1 Comments

Parsley Seafood Nachos:

1/2 cup of parsley flakes
1 large heaping tablespoonful of base sauce
1 large heaping tablespoonful of red salmon
1 ounce grated halbenero jack cheese
1/2 teaspoon of fresh ground pepper
1/2 teaspoon of ground red pepper, hot pepper sauce, or relish

optional:
1 large heaping tablespoonful of guacamole

Use the base sauce from the chutney recipe. The onion in the base sauce is important. Mash the ingredients together until well mixed. The guacamole adds much to the flavor and a nice consistency, but it also has alot of calories. I wouldn't use it every time. Spread the result over corn chips and microwave on high for 1 minute. Alternatively, it can be served cold as a vegetable dip. Add a little lemon juice if you like. The parsley provides the bulk, so that this is a fairly low calorie recipe. It has alot of flavor, so remember to go easy on the chips! A little cheese and salmon goes a long way with this recipe.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Follow Michael L. Love:
on Google Buzz

Posted Saturday, Feb 20, 2010 3:53 PM by proclus | 1 Comments

Osteoporosis and osteopenia were a topic of conversation in my department at Hopkins today, and as I listened to the discussion, it occurred to me that flavonoids like parsley apigenin might help to prevent adverse bone loss. It did not take much digging to find out that this is indeed the case, and there is even evidence that flavonoids may reverse bone loss. A quick search turned up this surprising statement from 2004.

Flavonoids are micronutrients widely present in food of plant origin. They have been attributed pharmacological properties such as anticancer and prevention of age-related pathologies. It has been recently hypothesized that flavonoids increase bone mass and prevent osteoporosis.
Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF?B and AP-1

It also occurred to me that the real problem is not the normal osteoclast cells, which are required for the repair and day-to-day maintenance of bone. The problem of bone loss more likely results from abnormal osteoclast cells, which have mutated in similar ways as cancer cells. Moreover, these cells exhibit an important property of cancer cells: they are highly invasive. It is not difficult to imagine that flavonoid molecules, like parsley apigenin, would attenuate this undesired and abnormal invasiveness of osteoclasts gone bad. High dose apigenin has been demonstrated to kill several types of abnormal cells. Killing abnormal osteoclasts may reverse bone loss.

Most importantly, the levels of flavonoid that are required to achieve some of these desirable effects are easily attainable using the methods described in this blog. In fact, the consumption of quercetin containing fruits has been demonstrated to reduce bone loss, and our methods increase the absorption of quercetin. Quercetin has been shown to have exceptional properties in the fight against bone loss, and parsley apigenin has been demonstrated to share in many of these same properties.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Follow Michael L. Love:
on Google Buzz

Posted Wednesday, Feb 17, 2010 9:44 PM by proclus | 0 Comments

Michael L. Love: Apigenin MOD

I thought people who have been following the blog might like to read the Apigenin page at the Molecules site.

Apigenin is probably the most inexpensive and widely available flavonoid, because it is present in more than 1:10 gram for gram quantities common parsley flakes in the form of apin. Apigenin is the resveratrol-like...

The molecule of the day is: Apigenin

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Posted Monday, Feb 15, 2010 3:48 PM by proclus | 0 Comments

Michael L. Love: Happy Valentines!

Hope that you enjoy this bit of verse. Be sure and pass the hugs around!

I love you!, some verse by Michael L. Love

Love, I am in a love lockdown.
It's love hate.
I say love you, not boy love.
I am fated to love you.
I want to say I love her.
I want to be your love guru, bad love.
Don't hate that I love you.
Don't say that I love money.
I want to play a lady gaga love game to you,
and say love sayings to you.
I will send you a love sms,
so that you will know that it is pure love.
I want to be in your love horoscope.
You have me in a love lock down.
It's not guy love.
It's not dvd love.
I want your love today.
Let's ride the rock of love bus.
It's not love and hate.
Be my computer love.
I love money 2.
Be in my love horoscopes.
We will be famous love,
and a love saying,
and cute love quotes,
love etc.
I'm in a love lock down.
It's skinny love.
It's your birthday love.
We will write the love definition,
and famous love quotes,
and sayings.

It's not love vs money,
or sad love quotes.
We should be the definition of love,
and famous love quotes.
You are my rock of love.
I love saying I love you,
but it is unrequited love,
bon iver skinny love,
e cards love.
We were love 2007,
and love inc,
and love shayari.
It was funny love quotes,
the dream of love vs money.
You are on my bratz love meter.
This is a real chance at love,
ashley rock of love,
and famous love poems.
I mean inspirational love,
the love letters of great men,
not love dvds,
or love ecards,
or love my flash.
We had sayings about love,
taya rock of love.
Write love poems for her,
and love sonnets.
It's valentines day love.
We need a free love calculator,
and a real chance of love girls.
To love and die,
for love 21,
is a free love test.

Write love poems for the one you love,
and you will need a true love calculator,
not an online love calculator,
to calculate your love.

Get me to the love calculator.

by Michael L. Love

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Posted Sunday, Feb 14, 2010 6:35 PM by proclus | 2 Comments

Michael L. Love: some reading and links

It was nice to see the influx of readers from the cooking and bicycling groups. Thank you for reading and for your suggestions. Some of these visitors may be interested in other types of links and reading, and here are a few.

My brother's blog
Certain Conditions
An italian blog about free and open source software
ossblog
A wonderful source of news about operating systems
OSNews.com
Blog-like free software advocacy site
advogato.org
A delightfully wacky ezine
Boing Boing
If you do not read Wikipedia, start now.
Wikipedia
A haven of e-activism
Zork
Web journal where the users are the editors
kuro5hin.org || technology and culture, from the trenches
One of my favorite sources for reading
Slashdot - News for nerds, stuff that matters

Enjoy your reading!

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Posted Wednesday, Feb 10, 2010 11:51 AM by proclus | 0 Comments

Michael L. Love: winter bicycling upshot

After some online forum discussion, there is much more that I can say about winter and urban bicycling, and more is sure to come. It is another snow day in Baltimore, and tomorrow probably as well, and it was great to think about something besides work. The midatlantic blizzard of 2010, though terrible, provided a fertile context for discussion of winter bicycling.

I have a practical commuter's perspective, that includes living close to your workplace. Although it is a key decision for a bicycle commuter, I think that it is merely wise. Living close to work would be a good idea for just about everyone, for many similar reasons as expressed in the article and more. Some people will decide to ride their bicycle to work after they have moved closer to their job, because it is so efficient and time-saving to combine the commute with the workout. In rush hour I regularly beat the cars across town on my bicycle.

The Dahon Curve that I ride has many advantages, but like any bicycle I suppose, it has quite a few disadvantages. It is my first ultra-light, which is great because it is so easy to carry and stow. With the 16 inch rims, I can easily turn it around inside an elevator. I think that the lighter metal is not as strong, and there is more wear and tear. I will probably get another Curve to replace this one, in spite of several misgivings including the cost. The advantages are far too great, and I have had two of them, so that I have quite a few spare parts. The style of the Curve is highly distinctive, and that is one of my favorite advantages. I have helmet mounted lights too. I want people to see the bicyclist, and I am often recognized around Baltimore because of this style of bicycling.

Bicycling helped make college affordable for me, which is part of the practical bicycle commuter's perspective, but I have been stewing about these ideas for years. It was a big relief to finally get it written down and published on the web. Although the storm is terrible in many places, it is fortunate for someone publishing on winter bicycling. As I said in the article, I have about 30 years of bicycle commuting experience. I am not sure that I would be so eager to brave the elements without that experience, and becoming an adept bicycle rider may be something of a prerequisite. Hopefully, people are not discouraged by that fact, because as the many bicycling clubs can attest, it is very fun to become adept. It is fun and beneficial in so many ways.

One time my hands got very cold while riding, and I vowed that it would never happen again. I have given this problem much attention. This aspect is a story unto itself, but I will skip it in the name of brevity. The solution of course depends on how cold it is, and the wind factor, and I find regular thin riding gloves or work gloves to be sufficient for chilly days. If it is windy and cold, more is needed. I have a pair of Trek heavy weather riding gloves, which is good for most of the winter season in Baltimore City. These gloves are also very convenient.

When I lived in Boston, it was often far colder than in Baltimore City, and the Trek gloves would not be warm enough for that. I used to live in Baltimore County as well, and I locked the bike up at one of the light rail stations for the commute, and it was sometimes almost as cold as Boston. Even in the city, there are days when the Trek gloves are not enough. In Boston, I used real heavy weather gear, which I learned from my Coast Guard training. Perhaps you have seen the bright wet suits that they use to get in the freezing water, avoid hypothermia, and save lives. I just used the gloves, which I believe were polypropylene, and I put wool lined deerskin mittens over them. I also experimented with camel hair mittens inside the deer skin. As a result of these measures, my hands were rarely very cold in Boston, and never as cold as that fateful day. These days, I put the deer skin mittens over the Trek gloves, which seems to be adequate for the coldest days. It is important when considering gloves that they not be too tight, so that blood circulation can warm the hands.

Another possible addition is ear muffs, which may be desirable for the coldest days. I didn't use them, even in Boston, and I got interesting dry flakes of skin on my ear lobes. They were rarely sore though. Some may consider ear muffs or face protection as a prerequisite for winter bicycling, but I have not personally found that to be the case. It should be noted that I do wear glasses, and some may wish to consider goggles.

I was certainly married with children in college and grad school, but that did not stop my bicycle commuting. Although my wife and I maintained the bicycle-only lifestyle for months into our marriage, she argued that she needed a car when she became pregnant, and I found the argument to be plausible for her. As the years progressed, it became very obvious that it was my wife's car, although she did help me out with a lift from time to time, and I borrowed it sometimes when the bicycle needed repairs. It is not difficult to see that someone with many children could need a car, although I would argue that the car should at least be dispensed with after the kids begin to become self-reliant. In fact, that is what we did. My wife (now ex) continues with this, but prefers public transportation. We have demonstrated that a car is not essential or required for daily living, although there may be a few exceptions. Since moving to Baltimore City, I have rented a car once or twice a year in order to get a few heavy errands done and make trips to the LDS temple in Washington DC. Cars do have their place, but I think they are extremely far overused in this society. I am delighted to see people try and minimize the impact of their automobiles, such as using small inexpensive vehicles and avoiding unnecessary travel or participation in automobile culture, which is adverse in so many ways.

I would like to thank the Johns Hopkins University, Williams College, and Research Triangle Park (RTP) cycling groups, and others for reading and commenting on the winter bicycling article. It has been a fabulous snow day activity.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Added Notes:
Comments continue coming in from around the web. This interesting comment came in from a member of the RTP group. They are clearly thinking in a similar vein, but from a touring and extreme sports perspective rather than commuting. I was excited to read the following.

Contrary to popular opinion, the bicycle makes a fairly good winter vehicle. This is not to suggest that care can be thrown to the winds. But with proper skill and technique, the bike provides safe and reliable transportation. It always starts, regardless of how cold it is. There are studded tires that make the most wicked slick ice manageable. It is easy to find a parking space, and it never gets stuck in the snow. Well, almost never.
ICEBIKE

Posted Tuesday, Feb 9, 2010 1:41 PM by proclus | 0 Comments

Michael L. Love: snow day

We have had an extraordinary amount of snow for Baltimore, and I have been stuck home for a few days, so not alot to report. I am using the time to make some spaghetti. I still feel a little strange adding 2 cups of parsley flakes to a pot of spaghetti, but the result is quite luscious, and of course, eminently healthful as well.

I am also trying to strike up some winter bicycling conversation in various online forums. Wish me luck. If the university were not closed, I would certainly have taken my bicycle to work, as usual. I ride in just about all weather. When I lived in Boston, we had this much snow and more almost every year, but that did not keep me off of my bicycle.

Maybe I will finally get around to putting up my chin-up bar today. I have springs and elastic bands, and I should certainly add some strength training to my regimen.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Posted Monday, Feb 8, 2010 2:49 PM by proclus | 0 Comments

Now that my eyes have been sensitized to dryness for the very first time in my life, I think that I can describe something I would call parsley eyes. They are apparently a little dryer than what they normally would be, even without any anti-histamine. In fact, my eyes have returned to normal, though perhaps occasionally on the dry side of normal. On my bicycle this morning, it was clear that my wet winter nose had returned. The stye is gone, and I stopped the niacin a day or two ago. Of course, the dryness would be linked to the CFTR blockade from the parsley regimen, but it also appears that a normal dose of anti-histamine was far too much, when combined with the parsley. I think that a few doses of niacin helped the stye recovery immensely, and now I think I am in the normal range, better than I was before.

This experience has taught me very much about the interplay between flavonoids and histamine. In the future, I may experiment with a very low dose of anti-histamine, which may be beneficial, if you can find one with high H1 receptor selectivity. Now that the dry eyes has been solved, I will be continuing with the parsley regimen for the foreseeable. There are just too many benefits from high dose polyphenol to give the parsley up, besides the fact that it is delicious.

This would be a good time to reiterate concerns around the use of flavonoid and polyphenol supplements with respect to development; pregnancy, nursing, and little children. As I have previously pointed out these concerns, I would only wish to indicate this caveat. For example, some women are using parsley in an attempt to restore or regularize menstruation. I don't know if it is effective, but if so, then there could obviously be a danger of miscarriage during pregnancy or worse.

Regards,
proclus
http://www.gnu-darwin.org/

Posted Friday, Feb 5, 2010 4:05 PM by proclus | 0 Comments

Yesterday I realized that people with allergies might like to try the parsley regimen. I have definitely had dry eyes and nose as a result of using this much parsley, and I think I actually developed an eye stye because of it. Of course, this speaks to the histamine connection. I had been taking an anti-histamine for atopic cough and runny nose, which are allergy-like symptoms, and it appears that the parsley regimen has eliminated that problem. Because of the stye, I stopped the anti-histamine, so that I would have more tears, and I have started taking niacin again, which I intend to do until the stye is gone. Today I have tears in my eyes, so that it appears that the combination of parsley regimen and anti-histamine was too strong for me. This is still preliminary in my case, but it would be wonderful if people could use parsley to reduce their allergy symptoms, and reduce or eliminate their anti-histamine use as indicated. It is clear that many who suffer from allergies or related problems would like to give this a try in order to get some relief. Parsley apigenin has been demonstrated to reduce cell invasiveness, which is a big part of the allergy problem and cancer too. My atopic cough is far better after two weeks of this parsley regimen. Research relates atopic cough directly to immune system invasion in the trachea. Perhaps we can add this parsley regimen to the body of allergy information and remedies. Time will tell. More later.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Posted Tuesday, Feb 2, 2010 9:47 AM by proclus | 0 Comments

How might apigenin chloride channel blockade decrease serum triglycerides? In other words, could one reduce serum triglycerides by eating parsley? What follows is abit speculative, and I will admit that I have not yet researched the topic fully in the literature. More will follow. If you are comfortable with the fact the following may contain inaccurate extrapolations, the proceed.

The first thing to observe is that a decrease in serum triglycerides would be a paradoxical effect. The channel blockade agents that are being considered here are also COX inhibitors and COX expression inhibitors, so that at low dose they can be expected to raise serum triglycerides, as observed.

At high dose, the agents would tend to raise the hydrostatic pressure of the cell, by blocking one of the primary means of reducing that pressure, the CFTR chloride channels. The physical model indicates, that increased hydrostatic pressure may lead to increased inward vesicular transport, and reduce serum triglycerides. The mechanism is unknown to me at this time.

Some things about the pathway and mechanism are known to me, for example, COX inhibitors would tend to raise serum triglycerides, because the product of the COX reaction, prostaglandins, binds to PPAR alpha and activates inward vesicular transport, probably by some genetic mechanism. It should be noted that prostaglandin production is the direct result of the activity of phospholipase, which provides the COX reagents.

One could hypothesize that a cellular response to CFTR blockade combined with COX inhibition would be the release of agents which activate phospholipase activity, such as histamine and norepinephrine. By doing this, the cell would be attempting to make more COX reagents, so that the inward vesicular transport can be turned on, perhaps in order to avoid hydrostatic rupture.

Hydrostatic rupture is probably an over-statement, and what we are discussing are more like tendencies, rather than requirements. One observation in support of this argument would be that cAMP-activated CFTR chloride permeabiltiy is able to overcome the blockade to varying degrees. The blockade is unlikely to be complete under cAMP-activated conditions. In fact, in cells which express cAMP coupled receptors, such as the beta-adenergic receptors, extra-cellular ligands to these receptors can be expected to alleviate hydrostatic pressure, without recourse to vesicular transport. Moreover, the cell likely has other means of releasing solutes to draw out water. For example, there is another important chloride channel, which may play a key role. More on that later.

Two of the ligands which can activate both phospholipase and cAMP production are histamine and adenergics, such as epinephrine and norepinephrine, and cellular secretion of these products would be expected to help relieve hydrostatic pressure, by activating both CFTR, and inward vesicular transport, even during CFTR blockade which tends to be partial. This cellular response may take time to come to full fruition, perhaps days or weeks.

It should be noted that alpha-1 and H1 activation leading to phospholipase activity is the very stress response that we are trying to avoid. Phospholipase activity is associated with many problems, being implicated in cancer for example, and one infers that phospholipase activators would have the same association.

My experience is consistent with adenergic activation resulting from CFTR blockade, but I will need another week or so to eliminate some extraneous factors. Such activation would also be consistent with some of the puzzling and unexpectedly elevated blood pressure readings that I have had transiently in recent days.

Are blockading levels of resveratrol or flavonoids beneficial in the overall sense? My parsley experience clearly rings a cautionary note, but the animal experiments are indicating that a higher dose is consistent with deeper CR memesis, and that it is more healthfully beneficial than a lower dose. Perhaps the explanation for this observation resides in the intestine, resulting from CFTR blockade, but it may also result from a greater increase in triglyceride transport, especially inward transport. I am anxiously awaiting my next blood triglyceride assay. I would also add that increasing water intake is recommended for the parsley regimen in order to compensate for the diminished mucous secretion, among other things.

Regards,
proclus
http://www.gnu-darwin.org/

Posted Friday, Jan 29, 2010 1:23 PM by proclus | 2 Comments

I don't know if I am the first person to eat a cup of parsley flakes every day. I doubt it, but there are not many reports. It is definitely a learning experience. For example, my eyes are a little dry, certainly due the CFTR inhibition by apigenin. It is only a little bothersome, and not severe. I have never had dry eyes in my life, and it is an interesting experience. I don't plan to resort to an eye wash. I may reduce my dose somewhat, but not yet, I am having too much fun.

As noted below, this program easily puts gram levels of flavonoids into your body, and as a plus, you will enjoy the marvellous parsley flavor as never before. Due to the high flavonoid content, there is a possible increased likelihood of intestinal blockage with prolonged use, again because of the CFTR blockade. If you are like me, you will merely experience more regularity, but as noted before, those who might have intestinal problems, such as cryptitis, should probably not use this much parsley.

It is remarkable how widespread the effects of CFTR blockade are in the body. My heartburn is much diminished since starting the parsley regimen, which would also be a consistent effect, since CFTR function is a key component of acid secretion in the stomach, as well as acid quenching in the duodenum. In fact, this is a key reason why cystic fibrosis patients require special diets, and enzyme supplementation. I would suspect that this is one reason why enzymes are so popular in the supplement community.

Another thing that I am noticing is a prolonged and enhanced effect of dextromorphan. This is confirmational of the finding that apigenin, like several other flavoniods, inhibits a p450 enzyme that is involved in dextromorphan metabolism, among several other drugs. A reduced dose may be indicated, and I will be getting my scheduled liver and kidney tests promptly. My experience is that this enhanced effect is profound, and my coughing symptoms have improved vastly. It should be noted at this point that this much parsley is quite diuretic as well.

These effects are not limited to parsley or apigenin, and there are quite a few polyphenols that are capable of producing a CFTR blockade, notably resveratrol. If you get very far above gram level dosing, you are also likely to experience similar effects with quercetin. The same is true for the p450 inhibition.

I am learning more about the parsley plant. For example, the root and seeds have much more of the other interesting parsley molecule, apiol, also known as parsley extract, parsley oil, or parsley camphor. There is much to say about apiol, but I will only give it a cursory treatment. There is much information about this molecule elsewhere on the web. The apiol extract is an anciently known preparation with many uses, including regularization of menstruation and an abortitive property. It is also somewhat dangerous, and there are even reported fatalities from ingesting too much apiol. Perhaps some young women, eager to restore their menstruation, unfortunately abused this chemical in the camphor form.

Apiol can have other unhealthful effects, and it has even been demonstrated to form DNA adducts, due to its extended reactive end-group. This is a commonplace problem associated with the 1-allyl side chain, which is found in many flavonoid producing plants. Unlike some other compounds, apiol forms weak adducts, which are apparently easily rectified in the cell, and there is much less apiol in the leaves, which is unlikely to present a problem.

I would be interested in hearing if any women are experiencing regularization of menstruation while on this parsley regimen. The effect may be small to nil, due to the comparitively low apiol content of the parsley flakes.

Well, this turned out to be rather exhuastive after all. Cheers!

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: Bisphenol Molecules Structural Archive and Gallery

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

Michael L. Love: Merry Christmas Vitacost Community!

Michael L. Love: Community blog to rss extraction code

Follow Michael L. Love:
on Google Buzz

Posted Monday, Jan 25, 2010 8:42 PM by proclus | 1 Comments

I have written a wee bit of code to make a custom rss feed from a Vitacost Community Blog. Anyone is free to use it as you like. Pass the result through rss2html.pl, and you get this...

The blog

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: Bisphenol Molecules Structural Archive and Gallery

You can see an implementation on the Molecules site. If you want help with an implementation, I'll take questions in the comments section. I may be making improvements according to suggestions, but I doubt it. Hope you enjoy the result. Cheers!

Regards,
proclus
http://www.gnu-darwin.org/

Posted Saturday, Jan 23, 2010 1:41 PM by proclus | 0 Comments

I have been commuting by bicycle for most of the last 30 years. This is the season that I get the most comments from people, who sometimes wonder how I manage to ride in the winter weather. I am delighted to see more bicyclists on the streets of Baltimore this winter, which means that there are more people who are committed urban bicycling. I ride a folding, ultra-lite, and I have posted several new photos, including a picture of my bicycle.

I don't own a car, and I work regular hours. It is about a 20-30 minute commute on my bicycle, and hilly, so that I get adequate exercise. I have daily incentive to do so, and wonder if I would get any exercise at all without this regimen.

Winter riding is only a little harder than other seasons. If there is snow, one must be mindful of the piles of snow, which commonly narrow the road, and make passage more difficult in traffic. Different types of snow present different problems, and possibilities are about endless, but you get the hang of it in time. Keeping an eye out for the occasional patch of ice is the main precaution. There is no quicker way to fall down on the pavement than to try and ride a bicycle on icy pavement. It feels very hard that way, especially in winter.

I started this regimen when I was 16 years old, because my girlfriend, Mary, lived about 5 miles away, and I did not own a car at the time. My parents demanded a strict curfew, and I always found myself racing home in order to beat the clock at the last minute. Later, I served a mission for the LDS church. Perhaps you have seen the young men in suits, riding bicycles in pairs. Maybe that was me. After my mission, I was committed to bicycle riding for health reasons, but also for the sake of the environment, and to save money. I live a far more comfortable lifestyle because I do not own a car, with its many expenses. I buy no gasoline, which makes good sense to me. Trust me, I am a lifer.

With all of my bicycling experience, I can manage the additional winter precautions very well. I have nice warm riding gloves, which addresses the main problem really, cold hands.

Urban riding in general presents additional challenges, such as broken glass, parallel storm drain gratings, railroad tracks, pot holes and other obstacles, and how to manage a small load of groceries or shopping items on the bicycle. Winter is just a little more to think about. It is good for the mind to think while under the stress of exercise, and these challenges give one plenty to think about, to say nothing about inconsiderate drivers. I am expecting research to show higher intelligence scores among life-long bicyclists. There are already hints in this direction.

Think about it; no contribution to pollution, free and easy parking near the entrance, no tedious trips to the gas station or repair shop, with those expenses, and no car insurance. You also have the satisfaction of knowing that you are not contributing to problems of US foreign policy or to the green house effect. If that were not all, you are contributing immensely to your overall health and well being, and you will be admired by many as well for all of these reasons and more, perhaps your great legs. Sell your car. Ride a bicycle. Do it now.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: winter bicycling follow up

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Follow Michael L. Love:
on Google Buzz

Posted Thursday, Jan 21, 2010 7:39 PM by proclus | 2 Comments

Michael L. Love: more parsley info, anti-diarrhea and other matters

Diarrhea is a frequently problem for those who undertake supplementation and vegetarian-style regimens. On the other hand, what for some of us is a minor inconvenience or annoyance can become life-threatening in some parts of the world where there are complicating issues. It is a real problem, which is larger than some of us think, and the dehydration resulting from diarrhea may be dangerous for those who are using supplements as well. First advice is drink plenty of water if you are using supplements. It should be noted that water shock can be fatal in severe cases.

As it happens, certain flavonoids have been documented to have a paradoxical anti-diarrhea property when taken in large doses. This is due to inhibition of the ATP-cAMP-dependent chloride channel (CFTR), and these flavonoids have been suggested as a remedy in cases where diarrhea might become dangerous. Parsley flavonoid shares in the ability to block this channel and slow digestion, so that water can be absorbed from the intestine.

Fortunately, parsley is a widely available commodity, even in some of the poorest of countries. I am recommending that an anti-diarrhea emulsion could include enough parsley to help save lives. It has been demonstrated that such inexpensive preparations can do great good. It can be flavored with a little sweetener for small children. Diarrhea can take its toll, particularly on the young, hopefully this information will help to prevent the death of some little ones.

Interestingly, the cystic fibrosis disease results from a defect in this same chloride channel. The wide range of symptoms indicate how widespread this channel is in the body, including the nasal passages and lungs. Those suffering from intestinal maladies, such as cryptitis, should consider avoiding such things as quercetin and parsley flakes. There is some evidence that we can find alternative flavonoid regimens for them, which do not inhibit the channel. I am including below a salient reference.

Regards,
proclus
http://www.gnu-darwin.org/

Cocoa-related flavonoids inhibit CFTR-mediated chloride transport across T84 human colon epithelia

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Follow Michael L. Love:
on Google Buzz

Posted Monday, Jan 18, 2010 8:36 PM by proclus | 2 Comments

I am calling the following Dr. Love's super flavonoid chutney for now. Many spices have a rather high flavonoid content, including thyme, fennel, and dill seeds, but parsley has far more. In fact, the health and nutrition benefits of parsley are probably incomparable to anything else, and my current recommendation is to eat up to 1 cup of dried parsley flakes every day. The aim is not necessarily the best taste, but rather to access parsley nutrition. Nicely, I found that parsley is a great vegetable and spice, so that the flavor can be modified to produce a tastey result. For example, I put a full cup of fresh parsley in my spaghetti this weekend, and the result was very pleasant. Parsley freshens and brightens the flavor of everything that it is added to.

Parsley is likely another superfood with more apigenin flavonoid than just about anything else on the planet. The dry flakes are roughly 10:1 apigenin gram for gram. Apigenin is the resveratrol-like flavonoid, and parsley apigenin is in the form of apin. Like resveratrol, the problem with apin and apigenin is that they are absorbed very poorly into the body, so this recipe employs familiar biochemical tricks to make them more accessible. (Kiss in waiting.) Parsley slows digestion and reduces gas, which might aid absorption, but I recommend a program of probiotics, yogurt and cheese in moderation, in order to aid that process. It might take a few weeks or more to get the full benefits. The recipe has well over a gram of flavonoids, especially if you add the capers. It is also very low calorie and highly flavorful.

I had to get creative in order to treat parsley as a vegetable instead of a spice, and this recipe is my first attempt. It is a chutney that has many uses, and can be easily modified for even more. It illustrates how to alter the taste of the parsley, in order to bring out the fruity astringent character. Cooking accentuates that aspect. Hope you like it.

Like many people, I keep a simple base tomato sauce in the fridge. You will need this for the recipe. This is a simple pepper-tomato-onion-basil sauce, which can be used in many different types of recipes. Other herbs, such as garlic, marjoram, oregano, cilantro, lemon, and hot peppers are all left out, so that their portions can be adjusted according to the needs of a particular recipe. (I also keep a jar of hot pepper relish, which can be prepared according to taste and used in the chutney. If you want instructions for the pepper relish, just ask.) There is a bottle of base sauce in my fridge at all times. Here is my base sauce recipe. Use medium to large vegetables.

1 tomato
2 red bell peppers
1 red onion
1 large sprig of fresh basil
2 capfuls of vinegar

Because of the preparation of the onions, this sauce keeps a long time in the fridge. The tomato is used to capture the sulfuric acid that is released from the onion, which makes the basil more interesting, It also gives the sauce its most important property; it is a strong, well-buffered acidic solution. It is necessary to work quicky to optimize this process. Slice the vegetables in half. Dice the basil in the food processor. Add the vinegar, tomato, and onion into the food processor and chop to desired size. Add peppers and chop to desired consistency. For the chutney, I recommend a fine chop, but not diced. Quickly put in a sealed container. Preparing the onion in this way will not make your eyes water, and it will also capture one of best qualities of the onion very well. Now for the chutney. The parsley is the centerpiece, but the result will be surprising.

1/2 cup parsley flakes
2 tablespoons red vinegar
1/2 teaspoon fresh ground black pepper or more
1 large heaping tablespoon plain yogurt
1/2 teaspoon flax or olive oil
1 tablespoon berry juice concentrate (I used elderberry)

for a special occasion,
1 small bottle of capers, diced

Mix ingredients well in a bowl, then mash together with a fork. Add 1 large heaping tablespoon of base sauce, and mix well. Add hot red pepper to taste. Enjoy!

This chutney can be used for many purposes. I topped my red salmon nachos off with nearly the whole bowl of it, and cooked it in the microwave for a couple of minutes. The result was quite pleasant, bringing out the fruity astringent character of the parsley. Overnight, the chutney taste did not degrade in a sealed container. (BTW, I think that with the raw parsley in the spaghetti sauce, overnight in the crock, it was the best spaghetti I ever made.)

The chutney is very low calorie, but it also has a very powerful flavor, and I considered many fattening foods that I might replace with it. Small adjustments can make a big difference. It tastes fine without the capers, and they are very salty, so don't use them very often unless you can find fresh raw ones without the salt. The capers add significantly to the flavonoid content, even by comparison to the parsley. Leave out the berry juice, and add a heaping teaspoon of garlic paste for something you can add to spagetti. Replace the base sauce and capers with citrus pulp for a pleasant fruit dish. Fruit vinegars might be preferred in that case, or you can use citrus and leave the vinegar out. Let me know what you think, and I can provide even more substitution ideas, if you don't have everything. The possibilities are truly endless, and I will likely be embellishing this idea in the future.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Posted Sunday, Jan 17, 2010 12:37 PM by proclus | 3 Comments

Michael L. Love: polyphenols and stable free radicals

Some of you might be interested in molecules that chemists use to form stable free radicals. It is remarkable how similar in structure some of them are to polyphenols, which probably helps to explain some of their properties. I would suspect that this kind of work underpins much of the supplementation that we do today. Chemistry is not my specialty, but I found this small collection to be very interesting, and probably valuable to someone.

free radical Molecules Structural Archive and Gallery

More interesting gallaries are in the pipeline. If you want to watch them as they roll out, subscribe by rss.

http://molecules.gnu-darwin.org/mod.rss

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: winter bicycling upshot

Follow Michael L. Love:
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Posted Thursday, Jan 14, 2010 4:54 PM by proclus | 0 Comments

Apr 2, 2010 10:35:51 AM

Michael L. Love: proclus molecules blog

After some online forum discussion, there is much more that I can say about winter and urban bicycling, and more is sure to come. It is another snow day in Baltimore, and tomorrow probably as well, and it was great to think about something besides work. The midatlantic blizzard of 2010, though terrible, provided a fertile context for discussion of winter bicycling.

I have a practical commuter's perspective, that includes living close to your workplace. Although it is a key decision for a bicycle commuter, I think that it is merely wise. Living close to work would be a good idea for just about everyone, for many similar reasons as expressed in the article and more. Some people will decide to ride their bicycle to work after they have moved closer to their job, because it is so efficient and time-saving to combine the commute with the workout. In rush hour I regularly beat the cars across town on my bicycle.

The Dahon Curve that I ride has many advantages, but like any bicycle I suppose, it has quite a few disadvantages. It is my first ultra-light, which is great because it is so easy to carry and stow. With the 16 inch rims, I can easily turn it around inside an elevator. I think that the lighter metal is not as strong, and there is more wear and tear. I will probably get another Curve to replace this one, in spite of several misgivings including the cost. The advantages are far too great, and I have had two of them, so that I have quite a few spare parts. The style of the Curve is highly distinctive, and that is one of my favorite advantages. I have helmet mounted lights too. I want people to see the bicyclist, and I am often recognized around Baltimore because of this style of bicycling.

Bicycling helped make college affordable for me, which is part of the practical bicycle commuter's perspective, but I have been stewing about these ideas for years. It was a big relief to finally get it written down and published on the web. Although the storm is terrible in many places, it is fortunate for someone publishing on winter bicycling. As I said in the article, I have about 30 years of bicycle commuting experience. I am not sure that I would be so eager to brave the elements without that experience, and becoming an adept bicycle rider may be something of a prerequisite. Hopefully, people are not discouraged by that fact, because as the many bicycling clubs can attest, it is very fun to become adept. It is fun and beneficial in so many ways.

One time my hands got very cold while riding, and I vowed that it would never happen again. I have given this problem much attention. This aspect is a story unto itself, but I will skip it in the name of brevity. The solution of course depends on how cold it is, and the wind factor, and I find regular thin riding gloves or work gloves to be sufficient for chilly days. If it is windy and cold, more is needed. I have a pair of Trek heavy weather riding gloves, which is good for most of the winter season in Baltimore City. These gloves are also very convenient.

When I lived in Boston, it was often far colder than in Baltimore City, and the Trek gloves would not be warm enough for that. I used to live in Baltimore County as well, and I locked the bike up at one of the light rail stations for the commute, and it was sometimes almost as cold as Boston. Even in the city, there are days when the Trek gloves are not enough. In Boston, I used real heavy weather gear, which I learned from my Coast Guard training. Perhaps you have seen the bright wet suits that they use to get in the freezing water, avoid hypothermia, and save lives. I just used the gloves, which I believe were polypropylene, and I put wool lined deerskin mittens over them. I also experimented with camel hair mittens inside the deer skin. As a result of these measures, my hands were rarely very cold in Boston, and never as cold as that fateful day. These days, I put the deer skin mittens over the Trek gloves, which seems to be adequate for the coldest days. It is important when considering gloves that they not be too tight, so that blood circulation can warm the hands.

Another possible addition is ear muffs, which may be desirable for the coldest days. I didn't use them, even in Boston, and I got interesting dry flakes of skin on my ear lobes. They were rarely sore though. Some may consider ear muffs or face protection as a prerequisite for winter bicycling, but I have not personally found that to be the case. It should be noted that I do wear glasses, and some may wish to consider goggles.

I was certainly married with children in college and grad school, but that did not stop my bicycle commuting. Although my wife and I maintained the bicycle-only lifestyle for months into our marriage, she argued that she needed a car when she became pregnant, and I found the argument to be plausible for her. As the years progressed, it became very obvious that it was my wife's car, although she did help me out with a lift from time to time, and I borrowed it sometimes when the bicycle needed repairs. It is not difficult to see that someone with many children could need a car, although I would argue that the car should at least be dispensed with after the kids begin to become self-reliant. In fact, that is what we did. My wife (now ex) continues with this, but prefers public transportation. We have demonstrated that a car is not essential or required for daily living, although there may be a few exceptions. Since moving to Baltimore City, I have rented a car once or twice a year in order to get a few heavy errands done and make trips to the LDS temple in Washington DC. Cars do have their place, but I think they are extremely far overused in this society. I am delighted to see people try and minimize the impact of their automobiles, such as using small inexpensive vehicles and avoiding unnecessary travel or participation in automobile culture, which is adverse in so many ways.

I would like to thank the Johns Hopkins University, Williams College, and Research Triangle Park (RTP) cycling groups, and others for reading and commenting on the winter bicycling article. It has been a fabulous snow day activity.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Added Notes:
Comments continue coming in from around the web. This interesting comment came in from a member of the RTP group. They are clearly thinking in a similar vein, but from a touring and extreme sports perspective rather than commuting. I was excited to read the following.

Contrary to popular opinion, the bicycle makes a fairly good winter vehicle. This is not to suggest that care can be thrown to the winds. But with proper skill and technique, the bike provides safe and reliable transportation. It always starts, regardless of how cold it is. There are studded tires that make the most wicked slick ice manageable. It is easy to find a parking space, and it never gets stuck in the snow. Well, almost never.
ICEBIKE

Posted Tuesday, Feb 9, 2010 1:41 PM by proclus | 0 Comments

Michael L. Love: snow day

We have had an extraordinary amount of snow for Baltimore, and I have been stuck home for a few days, so not alot to report. I am using the time to make some spaghetti. I still feel a little strange adding 2 cups of parsley flakes to a pot of spaghetti, but the result is quite luscious, and of course, eminently healthful as well.

I am also trying to strike up some winter bicycling conversation in various online forums. Wish me luck. If the university were not closed, I would certainly have taken my bicycle to work, as usual. I ride in just about all weather. When I lived in Boston, we had this much snow and more almost every year, but that did not keep me off of my bicycle.

Maybe I will finally get around to putting up my chin-up bar today. I have springs and elastic bands, and I should certainly add some strength training to my regimen.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Posted Monday, Feb 8, 2010 2:49 PM by proclus | 0 Comments

Now that my eyes have been sensitized to dryness for the very first time in my life, I think that I can describe something I would call parsley eyes. They are apparently a little dryer than what they normally would be, even without any anti-histamine. In fact, my eyes have returned to normal, though perhaps occasionally on the dry side of normal. On my bicycle this morning, it was clear that my wet winter nose had returned. The stye is gone, and I stopped the niacin a day or two ago. Of course, the dryness would be linked to the CFTR blockade from the parsley regimen, but it also appears that a normal dose of anti-histamine was far too much, when combined with the parsley. I think that a few doses of niacin helped the stye recovery immensely, and now I think I am in the normal range, better than I was before.

This experience has taught me very much about the interplay between flavonoids and histamine. In the future, I may experiment with a very low dose of anti-histamine, which may be beneficial, if you can find one with high H1 receptor selectivity. Now that the dry eyes has been solved, I will be continuing with the parsley regimen for the foreseeable. There are just too many benefits from high dose polyphenol to give the parsley up, besides the fact that it is delicious.

This would be a good time to reiterate concerns around the use of flavonoid and polyphenol supplements with respect to development; pregnancy, nursing, and little children. As I have previously pointed out these concerns, I would only wish to indicate this caveat. For example, some women are using parsley in an attempt to restore or regularize menstruation. I don't know if it is effective, but if so, then there could obviously be a danger of miscarriage during pregnancy or worse.

Regards,
proclus
http://www.gnu-darwin.org/

Posted Friday, Feb 5, 2010 4:05 PM by proclus | 0 Comments

Yesterday I realized that people with allergies might like to try the parsley regimen. I have definitely had dry eyes and nose as a result of using this much parsley, and I think I actually developed an eye stye because of it. Of course, this speaks to the histamine connection. I had been taking an anti-histamine for atopic cough and runny nose, which are allergy-like symptoms, and it appears that the parsley regimen has eliminated that problem. Because of the stye, I stopped the anti-histamine, so that I would have more tears, and I have started taking niacin again, which I intend to do until the stye is gone. Today I have tears in my eyes, so that it appears that the combination of parsley regimen and anti-histamine was too strong for me. This is still preliminary in my case, but it would be wonderful if people could use parsley to reduce their allergy symptoms, and reduce or eliminate their anti-histamine use as indicated. It is clear that many who suffer from allergies or related problems would like to give this a try in order to get some relief. Parsley apigenin has been demonstrated to reduce cell invasiveness, which is a big part of the allergy problem and cancer too. My atopic cough is far better after two weeks of this parsley regimen. Research relates atopic cough directly to immune system invasion in the trachea. Perhaps we can add this parsley regimen to the body of allergy information and remedies. Time will tell. More later.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Posted Tuesday, Feb 2, 2010 9:47 AM by proclus | 0 Comments

How might apigenin chloride channel blockade decrease serum triglycerides? In other words, could one reduce serum triglycerides by eating parsley? What follows is abit speculative, and I will admit that I have not yet researched the topic fully in the literature. More will follow. If you are comfortable with the fact the following may contain inaccurate extrapolations, the proceed.

The first thing to observe is that a decrease in serum triglycerides would be a paradoxical effect. The channel blockade agents that are being considered here are also COX inhibitors and COX expression inhibitors, so that at low dose they can be expected to raise serum triglycerides, as observed.

At high dose, the agents would tend to raise the hydrostatic pressure of the cell, by blocking one of the primary means of reducing that pressure, the CFTR chloride channels. The physical model indicates, that increased hydrostatic pressure may lead to increased inward vesicular transport, and reduce serum triglycerides. The mechanism is unknown to me at this time.

Some things about the pathway and mechanism are known to me, for example, COX inhibitors would tend to raise serum triglycerides, because the product of the COX reaction, prostaglandins, binds to PPAR alpha and activates inward vesicular transport, probably by some genetic mechanism. It should be noted that prostaglandin production is the direct result of the activity of phospholipase, which provides the COX reagents.

One could hypothesize that a cellular response to CFTR blockade combined with COX inhibition would be the release of agents which activate phospholipase activity, such as histamine and norepinephrine. By doing this, the cell would be attempting to make more COX reagents, so that the inward vesicular transport can be turned on, perhaps in order to avoid hydrostatic rupture.

Hydrostatic rupture is probably an over-statement, and what we are discussing are more like tendencies, rather than requirements. One observation in support of this argument would be that cAMP-activated CFTR chloride permeabiltiy is able to overcome the blockade to varying degrees. The blockade is unlikely to be complete under cAMP-activated conditions. In fact, in cells which express cAMP coupled receptors, such as the beta-adenergic receptors, extra-cellular ligands to these receptors can be expected to alleviate hydrostatic pressure, without recourse to vesicular transport. Moreover, the cell likely has other means of releasing solutes to draw out water. For example, there is another important chloride channel, which may play a key role. More on that later.

Two of the ligands which can activate both phospholipase and cAMP production are histamine and adenergics, such as epinephrine and norepinephrine, and cellular secretion of these products would be expected to help relieve hydrostatic pressure, by activating both CFTR, and inward vesicular transport, even during CFTR blockade which tends to be partial. This cellular response may take time to come to full fruition, perhaps days or weeks.

It should be noted that alpha-1 and H1 activation leading to phospholipase activity is the very stress response that we are trying to avoid. Phospholipase activity is associated with many problems, being implicated in cancer for example, and one infers that phospholipase activators would have the same association.

My experience is consistent with adenergic activation resulting from CFTR blockade, but I will need another week or so to eliminate some extraneous factors. Such activation would also be consistent with some of the puzzling and unexpectedly elevated blood pressure readings that I have had transiently in recent days.

Are blockading levels of resveratrol or flavonoids beneficial in the overall sense? My parsley experience clearly rings a cautionary note, but the animal experiments are indicating that a higher dose is consistent with deeper CR memesis, and that it is more healthfully beneficial than a lower dose. Perhaps the explanation for this observation resides in the intestine, resulting from CFTR blockade, but it may also result from a greater increase in triglyceride transport, especially inward transport. I am anxiously awaiting my next blood triglyceride assay. I would also add that increasing water intake is recommended for the parsley regimen in order to compensate for the diminished mucous secretion, among other things.

Regards,
proclus
http://www.gnu-darwin.org/

Posted Friday, Jan 29, 2010 1:23 PM by proclus | 2 Comments

I don't know if I am the first person to eat a cup of parsley flakes every day. I doubt it, but there are not many reports. It is definitely a learning experience. For example, my eyes are a little dry, certainly due the CFTR inhibition by apigenin. It is only a little bothersome, and not severe. I have never had dry eyes in my life, and it is an interesting experience. I don't plan to resort to an eye wash. I may reduce my dose somewhat, but not yet, I am having too much fun.

As noted below, this program easily puts gram levels of flavonoids into your body, and as a plus, you will enjoy the marvellous parsley flavor as never before. Due to the high flavonoid content, there is a possible increased likelihood of intestinal blockage with prolonged use, again because of the CFTR blockade. If you are like me, you will merely experience more regularity, but as noted before, those who might have intestinal problems, such as cryptitis, should probably not use this much parsley.

It is remarkable how widespread the effects of CFTR blockade are in the body. My heartburn is much diminished since starting the parsley regimen, which would also be a consistent effect, since CFTR function is a key component of acid secretion in the stomach, as well as acid quenching in the duodenum. In fact, this is a key reason why cystic fibrosis patients require special diets, and enzyme supplementation. I would suspect that this is one reason why enzymes are so popular in the supplement community.

Another thing that I am noticing is a prolonged and enhanced effect of dextromorphan. This is confirmational of the finding that apigenin, like several other flavoniods, inhibits a p450 enzyme that is involved in dextromorphan metabolism, among several other drugs. A reduced dose may be indicated, and I will be getting my scheduled liver and kidney tests promptly. My experience is that this enhanced effect is profound, and my coughing symptoms have improved vastly. It should be noted at this point that this much parsley is quite diuretic as well.

These effects are not limited to parsley or apigenin, and there are quite a few polyphenols that are capable of producing a CFTR blockade, notably resveratrol. If you get very far above gram level dosing, you are also likely to experience similar effects with quercetin. The same is true for the p450 inhibition.

I am learning more about the parsley plant. For example, the root and seeds have much more of the other interesting parsley molecule, apiol, also known as parsley extract, parsley oil, or parsley camphor. There is much to say about apiol, but I will only give it a cursory treatment. There is much information about this molecule elsewhere on the web. The apiol extract is an anciently known preparation with many uses, including regularization of menstruation and an abortitive property. It is also somewhat dangerous, and there are even reported fatalities from ingesting too much apiol. Perhaps some young women, eager to restore their menstruation, unfortunately abused this chemical in the camphor form.

Apiol can have other unhealthful effects, and it has even been demonstrated to form DNA adducts, due to its extended reactive end-group. This is a commonplace problem associated with the 1-allyl side chain, which is found in many flavonoid producing plants. Unlike some other compounds, apiol forms weak adducts, which are apparently easily rectified in the cell, and there is much less apiol in the leaves, which is unlikely to present a problem.

I would be interested in hearing if any women are experiencing regularization of menstruation while on this parsley regimen. The effect may be small to nil, due to the comparitively low apiol content of the parsley flakes.

Well, this turned out to be rather exhuastive after all. Cheers!

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: Bisphenol Molecules Structural Archive and Gallery

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

Michael L. Love: Merry Christmas Vitacost Community!

Michael L. Love: Community blog to rss extraction code

Follow Michael L. Love:
on Google Buzz

Posted Monday, Jan 25, 2010 8:42 PM by proclus | 1 Comments

I have written a wee bit of code to make a custom rss feed from a Vitacost Community Blog. Anyone is free to use it as you like. Pass the result through rss2html.pl, and you get this...

The blog

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: Bisphenol Molecules Structural Archive and Gallery

You can see an implementation on the Molecules site. If you want help with an implementation, I'll take questions in the comments section. I may be making improvements according to suggestions, but I doubt it. Hope you enjoy the result. Cheers!

Regards,
proclus
http://www.gnu-darwin.org/

Posted Saturday, Jan 23, 2010 1:41 PM by proclus | 0 Comments

I have been commuting by bicycle for most of the last 30 years. This is the season that I get the most comments from people, who sometimes wonder how I manage to ride in the winter weather. I am delighted to see more bicyclists on the streets of Baltimore this winter, which means that there are more people who are committed urban bicycling. I ride a folding, ultra-lite, and I have posted several new photos, including a picture of my bicycle.

I don't own a car, and I work regular hours. It is about a 20-30 minute commute on my bicycle, and hilly, so that I get adequate exercise. I have daily incentive to do so, and wonder if I would get any exercise at all without this regimen.

Winter riding is only a little harder than other seasons. If there is snow, one must be mindful of the piles of snow, which commonly narrow the road, and make passage more difficult in traffic. Different types of snow present different problems, and possibilities are about endless, but you get the hang of it in time. Keeping an eye out for the occasional patch of ice is the main precaution. There is no quicker way to fall down on the pavement than to try and ride a bicycle on icy pavement. It feels very hard that way, especially in winter.

I started this regimen when I was 16 years old, because my girlfriend, Mary, lived about 5 miles away, and I did not own a car at the time. My parents demanded a strict curfew, and I always found myself racing home in order to beat the clock at the last minute. Later, I served a mission for the LDS church. Perhaps you have seen the young men in suits, riding bicycles in pairs. Maybe that was me. After my mission, I was committed to bicycle riding for health reasons, but also for the sake of the environment, and to save money. I live a far more comfortable lifestyle because I do not own a car, with its many expenses. I buy no gasoline, which makes good sense to me. Trust me, I am a lifer.

With all of my bicycling experience, I can manage the additional winter precautions very well. I have nice warm riding gloves, which addresses the main problem really, cold hands.

Urban riding in general presents additional challenges, such as broken glass, parallel storm drain gratings, railroad tracks, pot holes and other obstacles, and how to manage a small load of groceries or shopping items on the bicycle. Winter is just a little more to think about. It is good for the mind to think while under the stress of exercise, and these challenges give one plenty to think about, to say nothing about inconsiderate drivers. I am expecting research to show higher intelligence scores among life-long bicyclists. There are already hints in this direction.

Think about it; no contribution to pollution, free and easy parking near the entrance, no tedious trips to the gas station or repair shop, with those expenses, and no car insurance. You also have the satisfaction of knowing that you are not contributing to problems of US foreign policy or to the green house effect. If that were not all, you are contributing immensely to your overall health and well being, and you will be admired by many as well for all of these reasons and more, perhaps your great legs. Sell your car. Ride a bicycle. Do it now.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: winter bicycling follow up

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Follow Michael L. Love:
on Google Buzz

Posted Thursday, Jan 21, 2010 7:39 PM by proclus | 2 Comments

Michael L. Love: more parsley info, anti-diarrhea and other matters

Diarrhea is a frequently problem for those who undertake supplementation and vegetarian-style regimens. On the other hand, what for some of us is a minor inconvenience or annoyance can become life-threatening in some parts of the world where there are complicating issues. It is a real problem, which is larger than some of us think, and the dehydration resulting from diarrhea may be dangerous for those who are using supplements as well. First advice is drink plenty of water if you are using supplements. It should be noted that water shock can be fatal in severe cases.

As it happens, certain flavonoids have been documented to have a paradoxical anti-diarrhea property when taken in large doses. This is due to inhibition of the ATP-cAMP-dependent chloride channel (CFTR), and these flavonoids have been suggested as a remedy in cases where diarrhea might become dangerous. Parsley flavonoid shares in the ability to block this channel and slow digestion, so that water can be absorbed from the intestine.

Fortunately, parsley is a widely available commodity, even in some of the poorest of countries. I am recommending that an anti-diarrhea emulsion could include enough parsley to help save lives. It has been demonstrated that such inexpensive preparations can do great good. It can be flavored with a little sweetener for small children. Diarrhea can take its toll, particularly on the young, hopefully this information will help to prevent the death of some little ones.

Interestingly, the cystic fibrosis disease results from a defect in this same chloride channel. The wide range of symptoms indicate how widespread this channel is in the body, including the nasal passages and lungs. Those suffering from intestinal maladies, such as cryptitis, should consider avoiding such things as quercetin and parsley flakes. There is some evidence that we can find alternative flavonoid regimens for them, which do not inhibit the channel. I am including below a salient reference.

Regards,
proclus
http://www.gnu-darwin.org/

Cocoa-related flavonoids inhibit CFTR-mediated chloride transport across T84 human colon epithelia

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Follow Michael L. Love:
on Google Buzz

Posted Monday, Jan 18, 2010 8:36 PM by proclus | 2 Comments

I am calling the following Dr. Love's super flavonoid chutney for now. Many spices have a rather high flavonoid content, including thyme, fennel, and dill seeds, but parsley has far more. In fact, the health and nutrition benefits of parsley are probably incomparable to anything else, and my current recommendation is to eat up to 1 cup of dried parsley flakes every day. The aim is not necessarily the best taste, but rather to access parsley nutrition. Nicely, I found that parsley is a great vegetable and spice, so that the flavor can be modified to produce a tastey result. For example, I put a full cup of fresh parsley in my spaghetti this weekend, and the result was very pleasant. Parsley freshens and brightens the flavor of everything that it is added to.

Parsley is likely another superfood with more apigenin flavonoid than just about anything else on the planet. The dry flakes are roughly 10:1 apigenin gram for gram. Apigenin is the resveratrol-like flavonoid, and parsley apigenin is in the form of apin. Like resveratrol, the problem with apin and apigenin is that they are absorbed very poorly into the body, so this recipe employs familiar biochemical tricks to make them more accessible. (Kiss in waiting.) Parsley slows digestion and reduces gas, which might aid absorption, but I recommend a program of probiotics, yogurt and cheese in moderation, in order to aid that process. It might take a few weeks or more to get the full benefits. The recipe has well over a gram of flavonoids, especially if you add the capers. It is also very low calorie and highly flavorful.

I had to get creative in order to treat parsley as a vegetable instead of a spice, and this recipe is my first attempt. It is a chutney that has many uses, and can be easily modified for even more. It illustrates how to alter the taste of the parsley, in order to bring out the fruity astringent character. Cooking accentuates that aspect. Hope you like it.

Like many people, I keep a simple base tomato sauce in the fridge. You will need this for the recipe. This is a simple pepper-tomato-onion-basil sauce, which can be used in many different types of recipes. Other herbs, such as garlic, marjoram, oregano, cilantro, lemon, and hot peppers are all left out, so that their portions can be adjusted according to the needs of a particular recipe. (I also keep a jar of hot pepper relish, which can be prepared according to taste and used in the chutney. If you want instructions for the pepper relish, just ask.) There is a bottle of base sauce in my fridge at all times. Here is my base sauce recipe. Use medium to large vegetables.

1 tomato
2 red bell peppers
1 red onion
1 large sprig of fresh basil
2 capfuls of vinegar

Because of the preparation of the onions, this sauce keeps a long time in the fridge. The tomato is used to capture the sulfuric acid that is released from the onion, which makes the basil more interesting, It also gives the sauce its most important property; it is a strong, well-buffered acidic solution. It is necessary to work quicky to optimize this process. Slice the vegetables in half. Dice the basil in the food processor. Add the vinegar, tomato, and onion into the food processor and chop to desired size. Add peppers and chop to desired consistency. For the chutney, I recommend a fine chop, but not diced. Quickly put in a sealed container. Preparing the onion in this way will not make your eyes water, and it will also capture one of best qualities of the onion very well. Now for the chutney. The parsley is the centerpiece, but the result will be surprising.

1/2 cup parsley flakes
2 tablespoons red vinegar
1/2 teaspoon fresh ground black pepper or more
1 large heaping tablespoon plain yogurt
1/2 teaspoon flax or olive oil
1 tablespoon berry juice concentrate (I used elderberry)

for a special occasion,
1 small bottle of capers, diced

Mix ingredients well in a bowl, then mash together with a fork. Add 1 large heaping tablespoon of base sauce, and mix well. Add hot red pepper to taste. Enjoy!

This chutney can be used for many purposes. I topped my red salmon nachos off with nearly the whole bowl of it, and cooked it in the microwave for a couple of minutes. The result was quite pleasant, bringing out the fruity astringent character of the parsley. Overnight, the chutney taste did not degrade in a sealed container. (BTW, I think that with the raw parsley in the spaghetti sauce, overnight in the crock, it was the best spaghetti I ever made.)

The chutney is very low calorie, but it also has a very powerful flavor, and I considered many fattening foods that I might replace with it. Small adjustments can make a big difference. It tastes fine without the capers, and they are very salty, so don't use them very often unless you can find fresh raw ones without the salt. The capers add significantly to the flavonoid content, even by comparison to the parsley. Leave out the berry juice, and add a heaping teaspoon of garlic paste for something you can add to spagetti. Replace the base sauce and capers with citrus pulp for a pleasant fruit dish. Fruit vinegars might be preferred in that case, or you can use citrus and leave the vinegar out. Let me know what you think, and I can provide even more substitution ideas, if you don't have everything. The possibilities are truly endless, and I will likely be embellishing this idea in the future.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Posted Sunday, Jan 17, 2010 12:37 PM by proclus | 3 Comments

Michael L. Love: polyphenols and stable free radicals

Some of you might be interested in molecules that chemists use to form stable free radicals. It is remarkable how similar in structure some of them are to polyphenols, which probably helps to explain some of their properties. I would suspect that this kind of work underpins much of the supplementation that we do today. Chemistry is not my specialty, but I found this small collection to be very interesting, and probably valuable to someone.

free radical Molecules Structural Archive and Gallery

More interesting gallaries are in the pipeline. If you want to watch them as they roll out, subscribe by rss.

http://molecules.gnu-darwin.org/mod.rss

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: some bio info, blog links, plus some molecules site news

Follow Michael L. Love:
on Google Buzz

Posted Thursday, Jan 14, 2010 4:54 PM by proclus | 0 Comments

I am adding molecules links throughout the blog, which should be more helpful to many readers who are researching supplements. It is pleasing to see the interest that is developing around the blog, and the molecules site activism. For those who are interested in learning some more about me, and why I am doing this, here is some reading. It is remarkable how an old bio sometimes retains its life and meaning. Here is my first bio on the web.

Michael L. Love: A personal statement

That one ends at Purdue. The links at the bottom of the bio can bring you up to date, and they are all listed in the links section of this blog as well. BTW, I find it surprising how many members have not added any links. I have looked at many of your links pages. If you add some, please let me know. Providing backlinks from other sites will raise the profile of your blog and promote our community. It will also help us to better understand what brought you here.

A better summary of the latest bio information is perhaps found on the GNU-Darwin site.

Michael L. Love on GNU-Darwin

Of special relevance is the Molecules site news. Like a blog, it is reverse chronological.

Molecules activism was first launched as an adjunct to GNU-Darwin, but I would not be surprised to see the subdomain eclipse GNU-Darwin some day. The subdomain continues to grow in profile. Our plan will take years and decades to complete, but the site is growing every day. Our next phase to add more accurate 3D molecular representations is set to begin soon. It is projected that Google will need a full year to crawl it once the additional information is in place, and we are still only getting started. It is projected that we will need new hardware not long after that, and hopefully there will be funds for that.

That is all for now. Don't forget to tell me, if you add links to your blog.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: Bisphenol Molecules Structural Archive and Gallery

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

Michael L. Love: Merry Christmas Vitacost Community!

Michael L. Love: USDA Database for the Flavonoid Content of Selected Foods

Follow Michael L. Love:
on Google Buzz

Posted Wednesday, Jan 13, 2010 5:13 PM by proclus | 1 Comments

Mainly still thinking about rutabagas, and I came across this wonderful thing. You are in for some surprises!

USDA Database for the Flavonoid Content of Selected Foods

Like many people, I am skeptical of information coming out of the US government, but this info has strong consistency with information obtained from other sources. Parsley, capers, and elderberry are a knockout. Elderberries remind me that I need a little detour to add cyanidin to the cross-comparison.

Obviously for weight watchers, you can use info like this from the USDA to get the most nutrution out of a small amount of food. Flavonoids often add a ton of flavor into a small amount of calories. The USDA also has a nice carotenoid database. Cheers!

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: recipe; flax oil, tyrosol lignans update

Follow Michael L. Love:
on Google Buzz

Posted Monday, Jan 11, 2010 3:01 PM by proclus | 0 Comments

This is another late night quick update on several items. I managed to isolate the effects of the flax oil with lignan fraction formulations, and I am checking off. I could not detect any increase in blood pressure, or any decongestant effect either. It is likely that this is a most healthful oil formulation, second only to certain fish oils.

I think that the lignans add a little bitter taste to this oil, which is comparable to some olive oils that may be similar, but I recommend the flax oil anyway. Cooking and acidic foods are likely to create something deeply pleasant from the bitters. In fact, I have a recipe for this below.

Before proceeding to the recipe, I would like to point out a problem with citrus bioflavonoids, like hesperidin and naringinin. Although citrus fruits typically have hundreds of milligrams of these beneficial substances, they are not absorbed well into the body. In fact, the absorption is terrible, in spite of the high vitamin C content of the fruit. One reason for this may be that people tend to wolf citrus fruits down without chewing, and I recommend small, well-chewed bites. I have also applied some biochemical insights and kitchen wizardry to make a recipe that attempts to address this problem.

Again, before proceeding to the recipe itself, I need to point out that this citrus pudding has a very unusual ingredient, fresh ground pepper. Like the flax oil bitters, this spice takes on a very different and rich taste in the acidic pudding mixture. Here is the recipe.

Juice two citrus fruits, and save the pulp. Set the juice aside, or drink it as you like. It is not a part of the pudding. The vast majority of healthful fiber and flavanoids are found in the pulp. Be sure to juice vigorously all the way to the peel. Put the pulp in a soup bowl, and add 1/2 teaspoon of vegetable oil. I am recommending the flax oil because of the high omega 3 and lignan content. Add 1/2 teaspoon of fresh ground pepper, and a large heaping tablespoon full of yogurt. Make sure that you have the kind with live cultures, because this will aid in the digestion of the fiber and absorption of the flavonoids. Like the flax lignans, this is very healthful fiber, and it is helpful to find a way to digest it. Stir the pudding to a thick uniform mixture, then enjoy your delicious treat.

I recommend experimenting with more pepper. The combination of citric acid and emulsion will remove any unpleasant taste, and like the other ingredients, the pepper may aid in absorption of the citrus bioflavanoids. Be sure and use fine ground fresh pepper.

If you have recommendations for this new recipe, be sure and post them. I am anxious to try them. I am really enjoying my citrus this way, and I promise a big wet kiss to anyone who can prove that it does not improve the absorption of these crucial nutrients. Enjoy your pudding. It is very filling and satisfying.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: Bisphenol Molecules Structural Archive and Gallery

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

Michael L. Love: Merry Christmas Vitacost Community!

Follow Michael L. Love:
on Google Buzz

Posted Sunday, Jan 10, 2010 8:03 PM by proclus | 2 Comments

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

I am following up with research on some of the foods on the list, particularly the ones that I am less familiar with. So I started with rutabagas, and this humble vegetable is taking far longer to research than I expected, which mostly explains why I haven't posted recently. There is rapeseed oil, canola, Monsanto, turnip greens, and much much more; each with research forks. It is really a marvellous subject, and there will likely be more in the future about this, but that is unfortunately all that I can say for now. I'll leave you with one of the more interesting references that I turned up, related to autism and iodine. Cheers!

Autism: transient in utero hypothyroxinemia related to maternal flavonoid ingestion during pregnancy and to other environmental antithyroid agents.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Merry Christmas Vitacost Community!

Follow Michael L. Love:
on Google Buzz

Posted Saturday, Jan 9, 2010 12:00 PM by proclus | 0 Comments

We are fortunately living in a time when the comparitive merit of the various polyphenols is being studied, so that we can survey the literature to find the best new supplements, and the best combinations. The first round of my survey has returned the following results. It supports my suggestion that one polyphenol supplement is not enough, and it is recommended to take a panel of them. This survey has its own bias as to time, because quercetin, resveratrol, egcg, and curcumin have received the most study, whereas hopeful prospects such as, silymarin, naringenin, apigenin, and kaempferol are new to the game in the comparitive studies.

Curcumin consistently scores highly, although not always the best. It is first mentioned, because it is rarely shown to have adverse effects. egcg and resveratrol, though getting frequent top scores, occasionally produce effects that are contrary to the aim. Quercetin is the midling, although it may be better grouped with curcumin. It is no surprise to see that curcumin, quercetin, and egcg are as popular in the supplement community, or more so, than resveratrol, due to the equally promising results that they have produced. I recommend a minimum panel of these four polyphenols taken together, each at their effective dose.

Other molecules that have received less attention, but score fairly well are naringenin, silymarin, and apigenin. Fisetin and chrysin dropped out in this round. I think that additional supplementation with naringenin, silymarin, and apigenin is not a bad idea. Other candidates will be coming to light in the future.

It should be noted that there are food sources which are often sufficient to provide the necessary amounts of many of these substances in order to produce the desired effect. These foods include citrus fruits, red onions, rutabagas, kale, as well as certain berries, grapes, and pomegranate. I would also recommend celery, thyme, parsley, and green peppers. (personally, I like the red peppers ;-)

I am afraid I that it is late for me tonight. I am tired, so that I am surely forgetting something, and there will certainly be further followup. I was able to produce a few more caveats and suggestions. I don't recommend more than 500 mg of egcg per day, until it can be demonstrated that a panel of polyphenols will prevent the resulting DNA strand breaks. This is an important concern, because it is easy to get far more that 500 mg of egcg from widely available supplements. The higher dose produces nPKC activation in keratinocytes and the resulting free radicals are shuttled to the nucleus by egcg. There is sure to be more about this type of problem in the future.

I would also like to point out that these molecules can inhibit COX enzymes and related systems, which is widely noted as a positive benefit. Unfortunately, oversuppression of COX may lead to kidney damage, due to the fact that the kidneys rely on prostaglandins for vasodilation. As a result of this realization, I have been monitoring my kidney function carefully using the chemistry panel tests, and I can say that it is very unwise to overuse NSAIDS and other COX inhibitors while on a polyphenol or flavanoid regimin. It is unwise in any case, so please review your use of these analgesic molecules, such as aspirin, ibuprofen, naproxen sodium etc. Check the directions again. My doctor is recommending acetaminophen instead, but I suggest using well below the recommended acetaminophen dose, especially when used in combination with aspirin. The molecular mechanisms of these two compounds are related. Supplementing with a strictly low dose of aspirin is probably still beneficial and possibly synergistic, as it were, with the polyphenol regimen, but I recommend regular kidney panels to anyone who is following the polyphenol or other CR-related regimens.

Relatedly, I have been experimenting with forskolin in order to provide an offset of vasodilation. Forskolin likely provides many healthful benefits in addition to this one, and it is probably not a bad idea to take it with your aspirin, but maintain a strict regimen. Use only small dose aspirin, and don't miss your forskolin doses, or you will experience the rollercoaster effect. You might also need an occasional dose of antacid with this combination. It is fashionable to avoid aluminum in the antacid.

Here is a bit more regarding the specific health concerns, with the supplements that score best in the respective studies. The lists are mostly in order of effectiveness. I also lists the supplements that didn't work. When it says "beats", this means that the supplement produced a contrary result to the aim; it was adverse.

resveratrol beats lutein
cures macular degeneration, anecdotal

resveratrol curcumin beats rutin quercetin
inhibited NADPH oxidase (NOX)

quercetin curcumin resveratrol beats rutin
prevented peroxide induced DNA single strand breaks

quercetin resveratrol curcumin beats egcg
phase 2 activation assay

quercetin apigenin beats egcg resveratrol
lung invasion test (cancer)

curcumin quercetin egcg beats resveratrol
immunosuppression

quercetin resveratrol beats egcg
xenobiotic response

curcumin egcg quercetin beats resveratrol
beneficial heme oxygenase1 expression upregulation

kaempferol naringenin beats egcg
catalase activity enhancement

egcg quercetin beats naringenin
radical scavenging

I hope that it is helpful to have the results summarized in this way. Here are the references, so that you can check for yourself.

Optometry. 2009 Dec;80(12):695-701.
Molecular medicine in ophthalmic care.
Richer S, Stiles W, Thomas C.

Biochem Biophys Res Commun. 2005 Jul 22;333(1):21-7.
Resveratrol and curcumin reduce the respiratory burst of Chlamydia-primed THP-1 cells.
Deby-Dupont G, Mouithys-Mickalad A, Serteyn D, Lamy M, Deby C.

Pharmazie. 2002 Dec;57(12):852-4.
Protection against damaged DNA in the single cell by polyphenols.
Liu GA, Zheng RL.

Toxicol Sci. 2007 Apr;96(2):227-36. Epub 2006 Oct 31.
Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.
Ebert B, Seidel A, Lampen A.

Nutr Cancer. 2004;49(2):200-8.
Phytoestrogens in common herbs regulate prostate cancer cell growth in vitro.
Shenouda NS, Zhou C, Browning JD, Ansell PJ, Sakla MS, Lubahn DB, Macdonald RS.

Int J Cancer. 2000 Aug 15;87(4):595-600.
Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential.
Caltagirone S, Rossi C, Poggi A, Ranelletti FO, Natali PG, Brunetti M, Aiello FB, Piantelli M.

Nutr Res. 2009 Aug;29(8):568-78.
Select phytochemicals suppress human T-lymphocytes and mouse splenocytes suggesting their use in autoimmunity and transplantation.
Hushmendy S, Jayakumar L, Hahn AB, Bhoiwala D, Bhoiwala DL, Crawford DR.

Free Radic Biol Med. 2007 Feb 1;42(3):315-25. Epub 2006 Oct 11.
Modulation of pregnane X receptor- and electrophile responsive element-mediated gene expression by dietary polyphenolic compounds.
Kluth D, Banning A, Paur I, Blomhoff R, Brigelius-Floh<E9> R.

Pharmacol Res. 2006 Feb;53(2):113-22. Epub 2005 Oct 21.
Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways.
Wung BS, Hsu MC, Wu CC, Hsieh CW.

Mutat Res. 2003 Feb-Mar;523-524:163-72.
Mechanism-based in vitro screening of potential cancer chemopreventive agents.
Gerh<E4>user C, Klimo K, Heiss E, Neumann I, Gamal-Eldeen A, Knauft J, Liu GY, Sitthimonchai S, Frank N.

"EGCG and EG partially suppressed catalase activity."
Biol Pharm Bull. 2007 Feb;30(2):213-7.
Chemical structure-dependent differential effects of flavonoids on the catalase activity as evaluated by a chemiluminescent method.
Doronicheva N, Yasui H, Sakurai H.

Arch Pharm Res. 2005 Nov;28(11):1293-301.
Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro.
Lyu SY, Rhim JY, Park WB.

Mutat Res. 2000 Apr 28;459(3):211-8.
Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA.
Johnson MK, Loo G.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: Bisphenol Molecules Structural Archive and Gallery

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

Michael L. Love: Merry Christmas Vitacost Community!

Follow Michael L. Love:
on Google Buzz

Posted Sunday, Jan 3, 2010 7:20 PM by proclus | 0 Comments

I would like to share my intitial impressions regarding tyrosol and lignins. I finally got a chance to try a couple of products containing these substances, and I was able to do a little checking, including some blood pressure measurements. I am borderline prehypertensive for various reasons, many of which are harmless, but I like to keep an eye on it. It should be noted that these impressions are preliminary, empirical, and anecdotal.

Lignins are a highly varied and often complex molecular species, so that it should always be inquired as to what type of lignans are being referred to. I am convinced that lignan molecules can be expected to be at the frontier of longevity medicine. It is no surprise that there is much excitement around these compounds, which have good free radical quenching capabilities, and similar structures to other polyphenolic compounds, which have been demonstrated to have enormously healthful benefits.

Tyrosol is another molecule which shares in the same interesting properties as lignans in the general sense, and in fact, many lignans are based on tyrosol. These include the lignins in flax and olive. Tyrosol has been demonstrated to have similar beneficial qualities, but it is also deserving of certain caveats, as are the tyrosol lignan class in general.

Tyrosol and tyrosol lignans are included in certain nasal and throat spray preparations, and it is not surprising that they exhibit a decongestant-like property, due to their similar structure to adenergic molecules, such as norepinephrine. In fact, tyrosol has been demonstrated to have antiarrhythmic effects, which could be beneficial for some people. This is consistent with alpha-1 adenergic activation, and explains the decongestant effect as well.

At this juncture, I would like to remind that these are preliminary findings, and people should search out the matter in the literature for themselves. My research is indicating at this time that alpha-1 activation is not beneficial from a longevity perspective, and is likely to cause harm to people with rapid heartbeat or high blood pressure. One reason for this is the resulting Akt activation, which you can look up for yourself. I try to avoid alpha-1 activation, which is a stress response. For this reason, I have until now tried to avoid decongestant medicines, which are typically alpha-1 adenergics.

Tyrosol shares its molecular properties with norepinephrin, the body's native alpha-1 receptor ligand, and as such it can be expected that there are ameliorating factors which offset the problems. Although, alpha-1 activation may lead to runaway calcium cascades, tyrosine kinase activation, and an increase in inflammatory factors, these effects which are often adverse are offset by the phenolic structure of the molecule, which may tend to scavange the resulting free radicals and produce some of the other benefits that are associated with polyphenols, like resveratrol.

My advice at this time is to use discretion and moderation when supplementing with tyrosol and tyrosol lignins. Consider the state of your health. Personally, with borderline prehypertension, I will tend to use less than some other people. For example, I will use the topical and intranasal preparations only as needed. I have the flax oil with lignan fraction preparation from NSI, and I think that it could be beneficial, but due to these concerns, I will limit myself to an occasional 1/2 teaspoon. I like it in my yogurt fruit smoothie, and it tastes better than olive oil in the juice. Much more could obviously be said about olive oils. Anyway, for people with low blood pressure and/or adverse congestion and swelling in the nasal epithelium, the effects may be more beneficial.

Adenergics are frequently a part of body building regimens, and I would advice caution. There are beta-adenergic agonists, which are probably more on target and effective than the alpha-1 agonists. Moreover, they can be expected to be more heathful in the general sense as well.

I am afraid that I am always eager to try the hottest new supplement, in order to expand my longevity program, and as a result, I do not always proceed with scientific rigor. I find myself backpedalling from time to time, which is why I put the caveats on this piece. I must confess that the observed effects could be due to a change in my vitamin E regimen, but I find that unlikely.

For the future, I think that tannins are in a similar preliminary state as lignins. There are huge potential benefits, but an equal degree of concerns. I hope that this information helps someone, and I will post updates as I learn more.

Incidentally, for those concerned about high blood pressure, you might want to have a look at forskolin. It is available in herbal extract form from NSI. I recommend a strict regimen when using forskolin, in order to avoid the rollercoaster effect. It would probably be wise to consult with a healthcare professional about it. I will probably have more to say about this later, as it is related to this story above.

Finally, I would like to boost another new idea. I think that phenolics which are not alpha-1 adenergic would be a better addition to an intranasal spray. It would not give users that familiar punch, but it would be more benefical in the long run. There are many naturally occuring flavonoids, which are known to have beneficial antimicrobal activity, and it should not be difficult to find the best one, perhaps among the citrus variety. In a suspension with a little citric acid to lower the pH and aid absorption, it could be quite beneficial and effective, without the alpha-1 body load... BTW, for the throat spray too.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: Bisphenol Molecules Structural Archive and Gallery

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

Michael L. Love: Merry Christmas Vitacost Community!

Michael L. Love: Bisphenol Molecules Structural Archive and Gallery

Follow Michael L. Love:
on Google Buzz

Posted Friday, Jan 1, 2010 7:06 PM by proclus | 0 Comments

I have automated the process to make molecule galleries, which I am finding very useful to my research, so I thought that I would share the opportunity and take requests. It is quick and easy. For example, I did a bisphenol search, and as I expected, the search turned up a few stilbenes, which is the same molecular family as resveratrol. Here is a link to one of our resveratrol galleries. Suprisingly, it also turned up some DDT-like molecules, which possibly indicates the care which must be exercised when using this class of molecules. For example, Bisphenol A is a noted teratogen, which demonstrates the caution which must be exercised when using such molecules during pregnancy, nursing, and development. Here is a link to the bisphenol gallery.

http://molecules.gnu-darwin.org/mod/Bisphenol-more.html

If you would find it useful, I am definitely interested in taking requests for molecule galleries. Be sure to check in the search box and mod directory, because we already have thousands of galleries, and thousands more are in the pipe now. Anyway, just send me the name of your favorite molecule.

As you may be able to tell, we have access for galleries to about 1% or 0.5 million structures, in the total archive thus far, but it is already quite useful. The automated jobs are underway to fill in the rest. The next milestone is the capability to index and make galleries for the remaining millions of molecules for which we have pdb files already, which would be 5-10% complete. As always, comments or suggestions are certainly welcome, and please feel free to pass along this info as you like.

Regards,

--
Michael L. Love Ph.D
Department of Biophysics and Biophysical Chemistry School of Medicine
Johns Hopkins University
725 N. Wolfe Street
Room 608B WBSB
Baltimore MD 21205-2185

Interoffice Mail: 608B WBSB, SoM

office: 410-614-2267
lab: 410-614-3179
fax: 410-502-6910
cell: 443-824-3451
http://www.gnu-darwin.org/

Visit proclus realm! http://proclus.tripod.com/
-----BEGIN GEEK CODE BLOCK-----
Version: 3.1
GMU/S d+@ s: a+ C++++ UBULI++++$ P+ L+++(++++) E--- W++ N- !o K- w--- !O M++@ V-- PS+++ PE Y+ PGP-- t+++(+) 5+++ X+ R tv-(--)@ b !DI D- G e++++ h--- r+++ y++++
------END GEEK CODE BLOCK------

The blog

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: Bisphenol Molecules Structural Archive and Gallery

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

Michael L. Love: Merry Christmas Vitacost Community!

Follow Michael L. Love:
on Google Buzz

Posted Friday, Jan 1, 2010 2:58 PM by proclus | 0 Comments

Happy New Year! Great things come in small packages! Do you remember the one with 10,000 terabytes of storage in the size of an acorn? Great things, like babies, and dream houses, and caviar; not to mention a small box of great supplements. Small things great. At this time of year may we all remember the small things which bring great blessings to our lives. Memories, and the precious centimeters between our ears. Let's be thankful and take care of our precious things. May we all have many more of them in the coming year!

Regards,
proclus
http://www.gnu-darwin.org/

PS, for mom

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love on GNU-Darwin.org
The Radical Mormon

Posted Thursday, Dec 31, 2009 5:24 PM by proclus | 2 Comments

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

I thought that the Vitacost community might be interested in the latest snippet from the Molecules site news, featuring Vitacost and this blog.

For those who are following the activism aspect of the Molecules site, I thought that you might be interested in a little pre-history as it were. Prior to the founding of the Molecules site, the activism first hatched under the GNU-Darwin umbrella, and the fundamental idea of molecules activism was invented. Initially, it was concerned primarily with resveratrol and other caloric restriction memetics, but it was clearly bound to expand from there. You can read some of the early material in the GNU-Darwin Posts regarding resveratrol and calorie restriction. As was previously mentioned, the ideas were formally developed in the FOSS, Science, and Public activism essay, and it was even put forth as a war protest in the so-called bootstrapping essay. As the Molecules site developed, it became clear that additional adjunct activities were required in order to push the activism harder. One of these adjuncts was created on the Vitacost website, where it is easy to provide directed links to crucial molecules for those who want to obtain them for themselves. Moreover, the activism ideas continue to evolve there in blog format. Check it out: Michael L. Love proclus Blog on Vitacost.

Tonight I found some very satisfying news related to all of this. One of the last few GNU-Darwin posts regarding resveratrol and caloric restriction referred to the very high anthocyanin content of the forbidden Thai black rice. You can read about that in the link above. At the time that I wrote the post there was virtually no product development around the black rice, but now I am happy to learn that there are many such products. Several can be found on the Vitacost website. Obviously, I cannot take any credit for this marvellous development, but the success is consistent with the activism ideas that I have been developing. There are many examples of such successes, some of them are documented in a free software activism article that I wrote several years ago. The implications are pretty far reaching. For more examples, check out this page on GNU-Darwin, or the links page and personal page of this blog. We also should consider the possibility that thinking in similar veins together makes great minds out of us. Of course the internet itself seems pre-designed for that sort of activism. Cheers!

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

Michael L. Love: Merry Christmas Vitacost Community!

Follow Michael L. Love:
on Google Buzz

Posted Monday, Dec 28, 2009 9:28 PM by proclus | 0 Comments

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

Hopefully this post will be Merry Christmas to someone. I am surprised by how hard it is to find antifungal nasal spray, as it is likely to address many health complaints. Thus far, I am not impressed with the herbal remedies that purport to do this, although I am willing to listen to any credible evidence. A big problem with some of the remedies is likely that they are not strong enough.

The spray should be strong enough to wipe out all fungal colonies in the nasal cavities, and it should also probably have antibacterial properties to prevent opportunistic infection. This will make the preparation very strong, and it is likely to cause some nasal dryness. Not to worry, because that will be a relief to most sufferers.

As for the health complaints, it is likely a very widespread problem, due to piggy backing on skin, mite, and insect particles, as well as the airborn spores, which are likely to lodge in the nasal cavities. Even overeating could cause the problem, due to nocturnal regurgitation. Personally, I live in an old red brick house in an urban setting near the sea. The old brick draws out moisture from the surrounding soil and air, and is likely furtile ground itself. Such conditions provide ample opportunity for the growth of mold and fungus, and I actually found overnight mushroom heads in my bathroom on a couple of occasions. (BTW, I keep a clean house, and follow the cleanup rules for allergy and asthma.). I have chronic post nasal drip and atopic cough. When I eat food , such as citrus fruits or red onions, with anti-fungal properties, my throat feels better immediately. Unfortunately, I can't stick tangerines up my nose ;-}, and with the post nasal drip, the condition returns. I am waiting for someone to capitalize on this good idea. I gladly will be your trusting guinea pig. Cheers!

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Merry Christmas Vitacost Community!

Michael L. Love: Merry Christmas Vitacost Community!

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Posted Friday, Dec 25, 2009 4:07 PM by proclus | 1 Comments

I have knocked together a kind of mockup Vitacost affilliate website. Let me know what you think.

Molecules@GNU-Darwin.org Vitacost Index

There are a few problems. I can make it update periodially with a cron job, so I would need a suggestion regarding the interval. Also, the links in the Health Daily items are broken, probably due to a shortcoming in my email extraction code. I am now tired and abit clueless about how to fix them at this moment. Hopefully I am not stepping on any toes ;-}. Anywho, enjoy! Cheers!

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

Michael L. Love: Merry Christmas Vitacost Community!

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Posted Thursday, Dec 24, 2009 6:48 PM by proclus | 0 Comments

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

I am expecting that the following polyphenols will be both highly effective and good free radical scanvengers as well. This is not based on any scientific evaluation, but rather on their widespread use and interest. People are not dummies. Work continues. Here is the list in order of priortity.

resveratrol, lutein, curcumin, quercetin, pycnogenol, rutin, egcg, silymarin, fucoidan, chrysin, diosmin, hesperidin, apigenin, luteolin, naringenin, kaempferol, fisetin, neohesperidin.

There is a wide range represented in the list, and right away I notice that lutein probably does not deserve such high placement in comparison to the others. There are some other possible misplacements, and biochemical insights will provide some refinements of the list. I cut the list very deep in order to include the citrus bioflavanoids, and it probably includes some less important molecules as a result. For example, I mentioned chrysin in a previous post as a possible problem, and rutin probably does not belong above egcg. More to come.

You can probably get a good approximation of this list by checking the Vitacost best sellers. Try searching on antioxidant. It is such a wonderful website, which helped me to compile this list and develop my program. Cheers!

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Merry Christmas Vitacost Community!

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Posted Wednesday, Dec 23, 2009 12:50 PM by proclus | 2 Comments

I grabbed the following information from my Amazon Seafood Wishlist, because I thought that it deserved more visibiltiy.

The healthful benefits of seafood are widely noted. I am searching for seafood which is low in mercury, high in DHA, and high in astaxanthin, and found that red salmon fills the bill.

DHA is one of the beneficial unsaturated omega 3 fatty acids, which is already widely known for its healthful benefits, and sure to be rising in prominence as well. Caviar is probably one of the best sources of DHA, far and away, and the red variety is also likely rich in astaxanthin, while the black variety is rich in melanin compounds, which are also likely to be healthful. One must be wary however of the food colorings that are used to produce the color in less expensive caviar. Due caution, and more information is needed. I have written an Amazon Guide about this. I am looking for inexpensive caviar that is also low in food coloring. See the wishlist for some examples. There are additional notes about some of the inexpensive caviars in the images section. I am projecting that the simple unprocessed salmon roe will be the best.

Astaxanthin is a carotene-like nutrient that is only available from red fish and certain shell fishes, such as shrimp. I have been told that shrimp are fed to fish in order to deepen their beneficial redness.

Sodium salt is a problem with seafood, but the benefits probably outweigh this problem, especially if you eliminate salt from other parts of your diet. Sodium is a particular problem for caviar, and it is probably unwise to eat unrinsed caviar. Better than rinsing, desalt the caviar. The eggs desalt rapidly because of their small size, and it improves the taste considerably. Don't use too much water though, because it will leach out the DHA. Just add enough water to cover over the eggs, stir gently to break up the clumps, let stand for a few minutes, then drain and rinse. Enjoy your caviar and salmon!

One more thing for Weight Loss Vitacosters, I have found that substituting red salmon and citrus fruits for calorie dense foods has reduced my hunger pangs considerably. Clearly, the salmon can be expected to be very satisfying. I have lost several pounds as a result of this change. I restrict the salmon to a heaping tablespoonful per meal, twice per day, which still provides a substantial amount of the mentioned nutrients.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

Michael L. Love: Merry Christmas Vitacost Community!

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Posted Tuesday, Dec 22, 2009 1:01 PM by proclus | 1 Comments

I would like te share a little regarding the current direction of my research. The subject may be familiar to most avid users of the Vitacost website. There is a problem with some of the phenolics in that they are
surprisingly not good free radical quenchers, and may in fact spread
free radical damages, if not worsen it. This needs to be better understood.

The importance of this subject becomes evident in consideration of
their binding near the reacting centers of COX enzymes, various
oxidases, and perioxidases. They are thus sequestered near centers of
free radical activity, and their ability to quench that activity is known to be a
crucial component of their functionality.

Chrysin is a flavanoid that is known to have relatively poor free radical quenching
activity, although it is able to bind and inhibit similar targets as
other polyphenols. Due to this fact, chrysin is less effective at
producing some of the key benefits of this class of molecules, and it may actually aggravate the damage caused by enzymes like myeloperoxidase. It is
known that there are other examples of this phenomena, and a survey of
the literature is indicated. Here is my research list. I have thrown in a few "errors", such as tomatoes and indoles for comparison and cross-checking purposes. Images of these molecules are available for your inspection on the Molecules site. Just put them names in the search box. There is much more to say, but perhaps some discussion is in order.

Polyphenol molecules:
Quercetin
EGCG
Silymarin
Resveratrol
Curcumin
Chrysin
Lutein
Kaempferol
Pycnogenol
Rutin
Apigenin
Luteolin
Hesperidin
Naringenin
Naringin
Neohesperidin
fucoidan
diosmin
fisetin
nobiletin

Polyphenol molecule classes:
procyanidins
flavanones
polyphenols
flavones
flavonoids
bioflavanoids
isoflavones
anthocyanidins
cyanidins
chalcones
lignins
tannins
indoles

Polyphenol and antioxidant rich foods:
black cherry
blueberry
cranberry
elderberry
raspberry
goji
pomegranate
acai berry
apple
muscadine
grape
red onion
red cabbage
citrus fruit
tomato
green tea
bilberry
wolfberry
seabuckthorn

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

Michael L. Love: Merry Christmas Vitacost Community!

Follow Michael L. Love:
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Posted Monday, Dec 21, 2009 9:33 PM by proclus | 0 Comments

A Google search on 'molecules activism' produces a page with Linus Pauling near the top. We are obviously in good company. The expired Nobel chemist makes a great example of an activist scientist, one that I have frequently admired. I got a chance to see him speak once, when I was at Phoenix College, and I was no less impressed. In truth, I have tried to emulate him in many ways. His crucial contributions to the world of chemistry and science in general are great enough, but he also drew much needed attention to the problems that society faced in his day. If only we could have more like him.

Also germane is the fact that he is a main reason why many of us are taking vitamin C, something which he continuously advocated. C is now indispensable for its ability to increase the absorbency of polyphenolic molecules, such as resveratrol. For those of us who are attempting to practice calorie restriction, C supplementation is a vital part of the program.    Hats off to Linus Pauling!

Regards,
Michael L. Love Ph.D
Department of Biophysics and Biophysical Chemistry
School of Medicine
Johns Hopkins University
725 N. Wolfe Street
Room 608B WBSB
Baltimore MD 21205-2185

Interoffice Mail: 608B WBSB, SoM
Shipping Dock: 1915 E. Madison St.

office: 410-614-2267
lab:    410-614-3179
fax:    410-502-6910
cell:   443-824-3451
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Follow Michael L. Love:
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Posted Saturday, Dec 19, 2009 8:25 PM by proclus | 2 Comments

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

My program is under constant development, and sites like Vitacost and Molecules are excellent tools for program development. I have included a few suggestions in my product recommendations section. Here is a link to my personal page, where you will find my supplement recommendations and product links.

http://community.vitacost.com/Templates/MyPage.aspx?UserID=4424

I am a happy but discontent person, and I always looking for ways to improve. I also eager to hear any suggestions and even criticism. Please feel free to write in.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Merry Christmas Vitacost Community!

Michael L. Love/GNU-Darwin Twitter Feed
Michael L. Love: blogging, facebook, and Radical Mormon
Michael L. Love: writing and riding
Michael L. Love: aspirin hiatus upshot
Michael L. Love: On value and money, molecules activism
Michael L. Love: aspirin hiatus
Michael L. Love: citrus pudding recipe
Michael L. Love: parsley recipe alert!
Michael L. Love: parsley and bone loss
Michael L. Love: Apigenin MOD
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Molecules@GNU-Darwin

naringenin-more
hesperidin-more
apigenin-more
methyl-ethyl-more
methyl-ethanol-more
methyl-drene-more
methyl-dopa-more
methyl-cyclohexanone-more
methyl-cyclohexanol-more
methyl-cuprate-more
methyl-carbamine-more
methyl-borate-more
methyl-beryllium-more
methyl-benzyl-more
methyl-benzilate-more
methyl-benzene-more
methyl-amyl-more
methyl-acrylate-more
methyl-5-phenyl-more

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The molecule of the day is: Apigenin
GNU-Darwin Action: another health care reform message
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On the loss of US credibility: conscription, death penalty
GNU-Darwin: Shell access, AMD Phenom Quad CPU
Apple Sued for iPhone Bricking
GNU-Darwin to support Iraq moratorium
GNU-Darwin OS on a Via CPU
Apple's Darwin OS still unfree and unusable
iPhone restricts users, GPLv3 frees them
End the war, Impeach!
Verizon Die!
Current actions: Impeach Cheney, Tell Abbott
Intel "open source fraud"?
Yager's latest...
Open-source Darwin? Not yet
The kernel building fiasco
GNU-Darwin: AMD Opteron support now
Action item: war and energy
U.S. Government Intervenes in EFF vs. ATT
Nature's way: resveratrol supplement
kill micro$oft
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GNU-Darwin Action: On value and money, molecules activism
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The molecule of the day is: Apigenin
GNU-Darwin Action: another health care reform message
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GNU-Darwin: blackout warning
On the loss of US credibility: conscription, death penalty
URGENT: Log a call against telecom immunity!
GNU-Darwin: Shell access, AMD Phenom Quad CPU
Apple Sued for iPhone Bricking
GNU-Darwin to support Iraq moratorium
GNU-Darwin OS on a Via CPU
Apple's Darwin OS still unfree and unusable
iPhone restricts users, GPLv3 frees them
End the war, Impeach!
Verizon Die!
Current actions: Impeach Cheney, Tell Abbott
Intel "open source fraud"?
Yager's latest...
Open-source Darwin? Not yet
The kernel building fiasco
GNU-Darwin: AMD Opteron support now
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U.S. Government Intervenes in EFF vs. ATT
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kill micro$oft
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Current actions: Impeach Cheney, Tell Abbott
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LDS World Gems bites the big one
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Worthy of the mantle
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Read the FAQ.

GNU-Darwin Posts about calorie restriction and the resveratrol
Michael L. Love on GNU-Darwin

Michael L. Love Curriculum Vitae

Michael Love: A Personal Statement

Three Years of Free Software Activism: The Case of GNU-Darwin OS

The GNU-Darwin Distribution 1.0: A Perspec tive from the Founder

Michael L. Love: proclus blog Relevant Links

Below are sites that to varying degrees shaped the ideas that were to become the content of this blog. Many Thanks to all of them!
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Re: [PyMOL] Molecule galleries
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cURL and libcurl
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Apple Developer Connection
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Cached.it
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Tom`s Hardware Guide - TÃ¼rkiye - TGForumz
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YPOPs! • Index page
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Gratisspullen - Gratis,free,gratissoftware,mooi,timothydegraaf
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groups.google.es
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hi.hiing.net
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Wikipedia, l'enciclopedia libera
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Jamz
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JeuxMots.fr : Jeux de Mots CroisÃ©s
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W3C Public Mailing List Archives
lists.w3.org

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Logistics Go - Logistics
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lwn.net

mac.linux.be

mac.wikia.com
MacApper | Mac Apps, Reviews, Previews, Interviews, and Giveaways.
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MacDevCenter.com-- macintosh development, open source development
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OSNews.com
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Wikipedia
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sourceforge.jp
SourceForge.net: Find and Develop Open Source Software
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spotindo.com
Stack Overflow
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Test Page for the Apache Web Server on Red Hat Linux
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Wikipedia, den fria encyklopedin
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swik.net
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www.wer-weiss-was.de
The GNU-Darwin Distribution
www.wireless-x.com
The GNU-Darwin Distribution
www.works2late.com
Personen / Info zu Name - Personen-Suchmaschine yasni.com
www.yasni.com
Personen / Info zu Name - Personen-Suchmaschine yasni.de
www.yasni.de

www.zoominfo.com
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www.zqds.gov.cn

www12.frugalware.org
CDF Padova
wwwcdf.pd.infn.it
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xm.domeng.cn

yebo-blog.blogspot.com
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yomi.mobi

ziddy.japan.zdnet.com
Cambalache 3,14 - La vidriera irrespetuosa
zifra.blogalia.com
Zopelana.org gunera
zopelana.org
Zork
zork.net

Posted Friday, Dec 18, 2009 10:23 PM by proclus | 0 Comments

Apr 2, 2010 10:34:29 AM

Michael L. Love: proclus molecules blog

Michael L. Love: polyphenols and stable free radicals

Some of you might be interested in molecules that chemists use to form stable free radicals. It is remarkable how similar in structure some of them are to polyphenols, which probably helps to explain some of their properties. I would suspect that this kind of work underpins much of the supplementation that we do today. Chemistry is not my specialty, but I found this small collection to be very interesting, and probably valuable to someone.

free radical Molecules Structural Archive and Gallery

More interesting gallaries are in the pipeline. If you want to watch them as they roll out, subscribe by rss.

http://molecules.gnu-darwin.org/mod.rss

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: some bio info, blog links, plus some molecules site news

Follow Michael L. Love:
on Google Buzz

Posted Thursday, Jan 14, 2010 4:54 PM by proclus | 0 Comments

I am adding molecules links throughout the blog, which should be more helpful to many readers who are researching supplements. It is pleasing to see the interest that is developing around the blog, and the molecules site activism. For those who are interested in learning some more about me, and why I am doing this, here is some reading. It is remarkable how an old bio sometimes retains its life and meaning. Here is my first bio on the web.

Michael L. Love: A personal statement

That one ends at Purdue. The links at the bottom of the bio can bring you up to date, and they are all listed in the links section of this blog as well. BTW, I find it surprising how many members have not added any links. I have looked at many of your links pages. If you add some, please let me know. Providing backlinks from other sites will raise the profile of your blog and promote our community. It will also help us to better understand what brought you here.

A better summary of the latest bio information is perhaps found on the GNU-Darwin site.

Michael L. Love on GNU-Darwin

Of special relevance is the Molecules site news. Like a blog, it is reverse chronological.

Molecules activism was first launched as an adjunct to GNU-Darwin, but I would not be surprised to see the subdomain eclipse GNU-Darwin some day. The subdomain continues to grow in profile. Our plan will take years and decades to complete, but the site is growing every day. Our next phase to add more accurate 3D molecular representations is set to begin soon. It is projected that Google will need a full year to crawl it once the additional information is in place, and we are still only getting started. It is projected that we will need new hardware not long after that, and hopefully there will be funds for that.

That is all for now. Don't forget to tell me, if you add links to your blog.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: Bisphenol Molecules Structural Archive and Gallery

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

Michael L. Love: Merry Christmas Vitacost Community!

Michael L. Love: USDA Database for the Flavonoid Content of Selected Foods

Follow Michael L. Love:
on Google Buzz

Posted Wednesday, Jan 13, 2010 5:13 PM by proclus | 1 Comments

Mainly still thinking about rutabagas, and I came across this wonderful thing. You are in for some surprises!

USDA Database for the Flavonoid Content of Selected Foods

Like many people, I am skeptical of information coming out of the US government, but this info has strong consistency with information obtained from other sources. Parsley, capers, and elderberry are a knockout. Elderberries remind me that I need a little detour to add cyanidin to the cross-comparison.

Obviously for weight watchers, you can use info like this from the USDA to get the most nutrution out of a small amount of food. Flavonoids often add a ton of flavor into a small amount of calories. The USDA also has a nice carotenoid database. Cheers!

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: recipe; flax oil, tyrosol lignans update

Follow Michael L. Love:
on Google Buzz

Posted Monday, Jan 11, 2010 3:01 PM by proclus | 0 Comments

This is another late night quick update on several items. I managed to isolate the effects of the flax oil with lignan fraction formulations, and I am checking off. I could not detect any increase in blood pressure, or any decongestant effect either. It is likely that this is a most healthful oil formulation, second only to certain fish oils.

I think that the lignans add a little bitter taste to this oil, which is comparable to some olive oils that may be similar, but I recommend the flax oil anyway. Cooking and acidic foods are likely to create something deeply pleasant from the bitters. In fact, I have a recipe for this below.

Before proceeding to the recipe, I would like to point out a problem with citrus bioflavonoids, like hesperidin and naringinin. Although citrus fruits typically have hundreds of milligrams of these beneficial substances, they are not absorbed well into the body. In fact, the absorption is terrible, in spite of the high vitamin C content of the fruit. One reason for this may be that people tend to wolf citrus fruits down without chewing, and I recommend small, well-chewed bites. I have also applied some biochemical insights and kitchen wizardry to make a recipe that attempts to address this problem.

Again, before proceeding to the recipe itself, I need to point out that this citrus pudding has a very unusual ingredient, fresh ground pepper. Like the flax oil bitters, this spice takes on a very different and rich taste in the acidic pudding mixture. Here is the recipe.

Juice two citrus fruits, and save the pulp. Set the juice aside, or drink it as you like. It is not a part of the pudding. The vast majority of healthful fiber and flavanoids are found in the pulp. Be sure to juice vigorously all the way to the peel. Put the pulp in a soup bowl, and add 1/2 teaspoon of vegetable oil. I am recommending the flax oil because of the high omega 3 and lignan content. Add 1/2 teaspoon of fresh ground pepper, and a large heaping tablespoon full of yogurt. Make sure that you have the kind with live cultures, because this will aid in the digestion of the fiber and absorption of the flavonoids. Like the flax lignans, this is very healthful fiber, and it is helpful to find a way to digest it. Stir the pudding to a thick uniform mixture, then enjoy your delicious treat.

I recommend experimenting with more pepper. The combination of citric acid and emulsion will remove any unpleasant taste, and like the other ingredients, the pepper may aid in absorption of the citrus bioflavanoids. Be sure and use fine ground fresh pepper.

If you have recommendations for this new recipe, be sure and post them. I am anxious to try them. I am really enjoying my citrus this way, and I promise a big wet kiss to anyone who can prove that it does not improve the absorption of these crucial nutrients. Enjoy your pudding. It is very filling and satisfying.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: Bisphenol Molecules Structural Archive and Gallery

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

Michael L. Love: Merry Christmas Vitacost Community!

Follow Michael L. Love:
on Google Buzz

Posted Sunday, Jan 10, 2010 8:03 PM by proclus | 2 Comments

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

I am following up with research on some of the foods on the list, particularly the ones that I am less familiar with. So I started with rutabagas, and this humble vegetable is taking far longer to research than I expected, which mostly explains why I haven't posted recently. There is rapeseed oil, canola, Monsanto, turnip greens, and much much more; each with research forks. It is really a marvellous subject, and there will likely be more in the future about this, but that is unfortunately all that I can say for now. I'll leave you with one of the more interesting references that I turned up, related to autism and iodine. Cheers!

Autism: transient in utero hypothyroxinemia related to maternal flavonoid ingestion during pregnancy and to other environmental antithyroid agents.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Merry Christmas Vitacost Community!

Follow Michael L. Love:
on Google Buzz

Posted Saturday, Jan 9, 2010 12:00 PM by proclus | 0 Comments

We are fortunately living in a time when the comparitive merit of the various polyphenols is being studied, so that we can survey the literature to find the best new supplements, and the best combinations. The first round of my survey has returned the following results. It supports my suggestion that one polyphenol supplement is not enough, and it is recommended to take a panel of them. This survey has its own bias as to time, because quercetin, resveratrol, egcg, and curcumin have received the most study, whereas hopeful prospects such as, silymarin, naringenin, apigenin, and kaempferol are new to the game in the comparitive studies.

Curcumin consistently scores highly, although not always the best. It is first mentioned, because it is rarely shown to have adverse effects. egcg and resveratrol, though getting frequent top scores, occasionally produce effects that are contrary to the aim. Quercetin is the midling, although it may be better grouped with curcumin. It is no surprise to see that curcumin, quercetin, and egcg are as popular in the supplement community, or more so, than resveratrol, due to the equally promising results that they have produced. I recommend a minimum panel of these four polyphenols taken together, each at their effective dose.

Other molecules that have received less attention, but score fairly well are naringenin, silymarin, and apigenin. Fisetin and chrysin dropped out in this round. I think that additional supplementation with naringenin, silymarin, and apigenin is not a bad idea. Other candidates will be coming to light in the future.

It should be noted that there are food sources which are often sufficient to provide the necessary amounts of many of these substances in order to produce the desired effect. These foods include citrus fruits, red onions, rutabagas, kale, as well as certain berries, grapes, and pomegranate. I would also recommend celery, thyme, parsley, and green peppers. (personally, I like the red peppers ;-)

I am afraid I that it is late for me tonight. I am tired, so that I am surely forgetting something, and there will certainly be further followup. I was able to produce a few more caveats and suggestions. I don't recommend more than 500 mg of egcg per day, until it can be demonstrated that a panel of polyphenols will prevent the resulting DNA strand breaks. This is an important concern, because it is easy to get far more that 500 mg of egcg from widely available supplements. The higher dose produces nPKC activation in keratinocytes and the resulting free radicals are shuttled to the nucleus by egcg. There is sure to be more about this type of problem in the future.

I would also like to point out that these molecules can inhibit COX enzymes and related systems, which is widely noted as a positive benefit. Unfortunately, oversuppression of COX may lead to kidney damage, due to the fact that the kidneys rely on prostaglandins for vasodilation. As a result of this realization, I have been monitoring my kidney function carefully using the chemistry panel tests, and I can say that it is very unwise to overuse NSAIDS and other COX inhibitors while on a polyphenol or flavanoid regimin. It is unwise in any case, so please review your use of these analgesic molecules, such as aspirin, ibuprofen, naproxen sodium etc. Check the directions again. My doctor is recommending acetaminophen instead, but I suggest using well below the recommended acetaminophen dose, especially when used in combination with aspirin. The molecular mechanisms of these two compounds are related. Supplementing with a strictly low dose of aspirin is probably still beneficial and possibly synergistic, as it were, with the polyphenol regimen, but I recommend regular kidney panels to anyone who is following the polyphenol or other CR-related regimens.

Relatedly, I have been experimenting with forskolin in order to provide an offset of vasodilation. Forskolin likely provides many healthful benefits in addition to this one, and it is probably not a bad idea to take it with your aspirin, but maintain a strict regimen. Use only small dose aspirin, and don't miss your forskolin doses, or you will experience the rollercoaster effect. You might also need an occasional dose of antacid with this combination. It is fashionable to avoid aluminum in the antacid.

Here is a bit more regarding the specific health concerns, with the supplements that score best in the respective studies. The lists are mostly in order of effectiveness. I also lists the supplements that didn't work. When it says "beats", this means that the supplement produced a contrary result to the aim; it was adverse.

resveratrol beats lutein
cures macular degeneration, anecdotal

resveratrol curcumin beats rutin quercetin
inhibited NADPH oxidase (NOX)

quercetin curcumin resveratrol beats rutin
prevented peroxide induced DNA single strand breaks

quercetin resveratrol curcumin beats egcg
phase 2 activation assay

quercetin apigenin beats egcg resveratrol
lung invasion test (cancer)

curcumin quercetin egcg beats resveratrol
immunosuppression

quercetin resveratrol beats egcg
xenobiotic response

curcumin egcg quercetin beats resveratrol
beneficial heme oxygenase1 expression upregulation

kaempferol naringenin beats egcg
catalase activity enhancement

egcg quercetin beats naringenin
radical scavenging

I hope that it is helpful to have the results summarized in this way. Here are the references, so that you can check for yourself.

Optometry. 2009 Dec;80(12):695-701.
Molecular medicine in ophthalmic care.
Richer S, Stiles W, Thomas C.

Biochem Biophys Res Commun. 2005 Jul 22;333(1):21-7.
Resveratrol and curcumin reduce the respiratory burst of Chlamydia-primed THP-1 cells.
Deby-Dupont G, Mouithys-Mickalad A, Serteyn D, Lamy M, Deby C.

Pharmazie. 2002 Dec;57(12):852-4.
Protection against damaged DNA in the single cell by polyphenols.
Liu GA, Zheng RL.

Toxicol Sci. 2007 Apr;96(2):227-36. Epub 2006 Oct 31.
Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.
Ebert B, Seidel A, Lampen A.

Nutr Cancer. 2004;49(2):200-8.
Phytoestrogens in common herbs regulate prostate cancer cell growth in vitro.
Shenouda NS, Zhou C, Browning JD, Ansell PJ, Sakla MS, Lubahn DB, Macdonald RS.

Int J Cancer. 2000 Aug 15;87(4):595-600.
Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential.
Caltagirone S, Rossi C, Poggi A, Ranelletti FO, Natali PG, Brunetti M, Aiello FB, Piantelli M.

Nutr Res. 2009 Aug;29(8):568-78.
Select phytochemicals suppress human T-lymphocytes and mouse splenocytes suggesting their use in autoimmunity and transplantation.
Hushmendy S, Jayakumar L, Hahn AB, Bhoiwala D, Bhoiwala DL, Crawford DR.

Free Radic Biol Med. 2007 Feb 1;42(3):315-25. Epub 2006 Oct 11.
Modulation of pregnane X receptor- and electrophile responsive element-mediated gene expression by dietary polyphenolic compounds.
Kluth D, Banning A, Paur I, Blomhoff R, Brigelius-Floh<E9> R.

Pharmacol Res. 2006 Feb;53(2):113-22. Epub 2005 Oct 21.
Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways.
Wung BS, Hsu MC, Wu CC, Hsieh CW.

Mutat Res. 2003 Feb-Mar;523-524:163-72.
Mechanism-based in vitro screening of potential cancer chemopreventive agents.
Gerh<E4>user C, Klimo K, Heiss E, Neumann I, Gamal-Eldeen A, Knauft J, Liu GY, Sitthimonchai S, Frank N.

"EGCG and EG partially suppressed catalase activity."
Biol Pharm Bull. 2007 Feb;30(2):213-7.
Chemical structure-dependent differential effects of flavonoids on the catalase activity as evaluated by a chemiluminescent method.
Doronicheva N, Yasui H, Sakurai H.

Arch Pharm Res. 2005 Nov;28(11):1293-301.
Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro.
Lyu SY, Rhim JY, Park WB.

Mutat Res. 2000 Apr 28;459(3):211-8.
Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA.
Johnson MK, Loo G.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: Bisphenol Molecules Structural Archive and Gallery

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

Michael L. Love: Merry Christmas Vitacost Community!

Follow Michael L. Love:
on Google Buzz

Posted Sunday, Jan 3, 2010 7:20 PM by proclus | 0 Comments

I would like to share my intitial impressions regarding tyrosol and lignins. I finally got a chance to try a couple of products containing these substances, and I was able to do a little checking, including some blood pressure measurements. I am borderline prehypertensive for various reasons, many of which are harmless, but I like to keep an eye on it. It should be noted that these impressions are preliminary, empirical, and anecdotal.

Lignins are a highly varied and often complex molecular species, so that it should always be inquired as to what type of lignans are being referred to. I am convinced that lignan molecules can be expected to be at the frontier of longevity medicine. It is no surprise that there is much excitement around these compounds, which have good free radical quenching capabilities, and similar structures to other polyphenolic compounds, which have been demonstrated to have enormously healthful benefits.

Tyrosol is another molecule which shares in the same interesting properties as lignans in the general sense, and in fact, many lignans are based on tyrosol. These include the lignins in flax and olive. Tyrosol has been demonstrated to have similar beneficial qualities, but it is also deserving of certain caveats, as are the tyrosol lignan class in general.

Tyrosol and tyrosol lignans are included in certain nasal and throat spray preparations, and it is not surprising that they exhibit a decongestant-like property, due to their similar structure to adenergic molecules, such as norepinephrine. In fact, tyrosol has been demonstrated to have antiarrhythmic effects, which could be beneficial for some people. This is consistent with alpha-1 adenergic activation, and explains the decongestant effect as well.

At this juncture, I would like to remind that these are preliminary findings, and people should search out the matter in the literature for themselves. My research is indicating at this time that alpha-1 activation is not beneficial from a longevity perspective, and is likely to cause harm to people with rapid heartbeat or high blood pressure. One reason for this is the resulting Akt activation, which you can look up for yourself. I try to avoid alpha-1 activation, which is a stress response. For this reason, I have until now tried to avoid decongestant medicines, which are typically alpha-1 adenergics.

Tyrosol shares its molecular properties with norepinephrin, the body's native alpha-1 receptor ligand, and as such it can be expected that there are ameliorating factors which offset the problems. Although, alpha-1 activation may lead to runaway calcium cascades, tyrosine kinase activation, and an increase in inflammatory factors, these effects which are often adverse are offset by the phenolic structure of the molecule, which may tend to scavange the resulting free radicals and produce some of the other benefits that are associated with polyphenols, like resveratrol.

My advice at this time is to use discretion and moderation when supplementing with tyrosol and tyrosol lignins. Consider the state of your health. Personally, with borderline prehypertension, I will tend to use less than some other people. For example, I will use the topical and intranasal preparations only as needed. I have the flax oil with lignan fraction preparation from NSI, and I think that it could be beneficial, but due to these concerns, I will limit myself to an occasional 1/2 teaspoon. I like it in my yogurt fruit smoothie, and it tastes better than olive oil in the juice. Much more could obviously be said about olive oils. Anyway, for people with low blood pressure and/or adverse congestion and swelling in the nasal epithelium, the effects may be more beneficial.

Adenergics are frequently a part of body building regimens, and I would advice caution. There are beta-adenergic agonists, which are probably more on target and effective than the alpha-1 agonists. Moreover, they can be expected to be more heathful in the general sense as well.

I am afraid that I am always eager to try the hottest new supplement, in order to expand my longevity program, and as a result, I do not always proceed with scientific rigor. I find myself backpedalling from time to time, which is why I put the caveats on this piece. I must confess that the observed effects could be due to a change in my vitamin E regimen, but I find that unlikely.

For the future, I think that tannins are in a similar preliminary state as lignins. There are huge potential benefits, but an equal degree of concerns. I hope that this information helps someone, and I will post updates as I learn more.

Incidentally, for those concerned about high blood pressure, you might want to have a look at forskolin. It is available in herbal extract form from NSI. I recommend a strict regimen when using forskolin, in order to avoid the rollercoaster effect. It would probably be wise to consult with a healthcare professional about it. I will probably have more to say about this later, as it is related to this story above.

Finally, I would like to boost another new idea. I think that phenolics which are not alpha-1 adenergic would be a better addition to an intranasal spray. It would not give users that familiar punch, but it would be more benefical in the long run. There are many naturally occuring flavonoids, which are known to have beneficial antimicrobal activity, and it should not be difficult to find the best one, perhaps among the citrus variety. In a suspension with a little citric acid to lower the pH and aid absorption, it could be quite beneficial and effective, without the alpha-1 body load... BTW, for the throat spray too.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: Bisphenol Molecules Structural Archive and Gallery

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

Michael L. Love: Merry Christmas Vitacost Community!

Michael L. Love: Bisphenol Molecules Structural Archive and Gallery

Follow Michael L. Love:
on Google Buzz

Posted Friday, Jan 1, 2010 7:06 PM by proclus | 0 Comments

I have automated the process to make molecule galleries, which I am finding very useful to my research, so I thought that I would share the opportunity and take requests. It is quick and easy. For example, I did a bisphenol search, and as I expected, the search turned up a few stilbenes, which is the same molecular family as resveratrol. Here is a link to one of our resveratrol galleries. Suprisingly, it also turned up some DDT-like molecules, which possibly indicates the care which must be exercised when using this class of molecules. For example, Bisphenol A is a noted teratogen, which demonstrates the caution which must be exercised when using such molecules during pregnancy, nursing, and development. Here is a link to the bisphenol gallery.

http://molecules.gnu-darwin.org/mod/Bisphenol-more.html

If you would find it useful, I am definitely interested in taking requests for molecule galleries. Be sure to check in the search box and mod directory, because we already have thousands of galleries, and thousands more are in the pipe now. Anyway, just send me the name of your favorite molecule.

As you may be able to tell, we have access for galleries to about 1% or 0.5 million structures, in the total archive thus far, but it is already quite useful. The automated jobs are underway to fill in the rest. The next milestone is the capability to index and make galleries for the remaining millions of molecules for which we have pdb files already, which would be 5-10% complete. As always, comments or suggestions are certainly welcome, and please feel free to pass along this info as you like.

Regards,

--
Michael L. Love Ph.D
Department of Biophysics and Biophysical Chemistry School of Medicine
Johns Hopkins University
725 N. Wolfe Street
Room 608B WBSB
Baltimore MD 21205-2185

Interoffice Mail: 608B WBSB, SoM

office: 410-614-2267
lab: 410-614-3179
fax: 410-502-6910
cell: 443-824-3451
http://www.gnu-darwin.org/

Visit proclus realm! http://proclus.tripod.com/
-----BEGIN GEEK CODE BLOCK-----
Version: 3.1
GMU/S d+@ s: a+ C++++ UBULI++++$ P+ L+++(++++) E--- W++ N- !o K- w--- !O M++@ V-- PS+++ PE Y+ PGP-- t+++(+) 5+++ X+ R tv-(--)@ b !DI D- G e++++ h--- r+++ y++++
------END GEEK CODE BLOCK------

The blog

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: Bisphenol Molecules Structural Archive and Gallery

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

Michael L. Love: Merry Christmas Vitacost Community!

Follow Michael L. Love:
on Google Buzz

Posted Friday, Jan 1, 2010 2:58 PM by proclus | 0 Comments

Happy New Year! Great things come in small packages! Do you remember the one with 10,000 terabytes of storage in the size of an acorn? Great things, like babies, and dream houses, and caviar; not to mention a small box of great supplements. Small things great. At this time of year may we all remember the small things which bring great blessings to our lives. Memories, and the precious centimeters between our ears. Let's be thankful and take care of our precious things. May we all have many more of them in the coming year!

Regards,
proclus
http://www.gnu-darwin.org/

PS, for mom

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love on GNU-Darwin.org
The Radical Mormon

Posted Thursday, Dec 31, 2009 5:24 PM by proclus | 2 Comments

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

I thought that the Vitacost community might be interested in the latest snippet from the Molecules site news, featuring Vitacost and this blog.

For those who are following the activism aspect of the Molecules site, I thought that you might be interested in a little pre-history as it were. Prior to the founding of the Molecules site, the activism first hatched under the GNU-Darwin umbrella, and the fundamental idea of molecules activism was invented. Initially, it was concerned primarily with resveratrol and other caloric restriction memetics, but it was clearly bound to expand from there. You can read some of the early material in the GNU-Darwin Posts regarding resveratrol and calorie restriction. As was previously mentioned, the ideas were formally developed in the FOSS, Science, and Public activism essay, and it was even put forth as a war protest in the so-called bootstrapping essay. As the Molecules site developed, it became clear that additional adjunct activities were required in order to push the activism harder. One of these adjuncts was created on the Vitacost website, where it is easy to provide directed links to crucial molecules for those who want to obtain them for themselves. Moreover, the activism ideas continue to evolve there in blog format. Check it out: Michael L. Love proclus Blog on Vitacost.

Tonight I found some very satisfying news related to all of this. One of the last few GNU-Darwin posts regarding resveratrol and caloric restriction referred to the very high anthocyanin content of the forbidden Thai black rice. You can read about that in the link above. At the time that I wrote the post there was virtually no product development around the black rice, but now I am happy to learn that there are many such products. Several can be found on the Vitacost website. Obviously, I cannot take any credit for this marvellous development, but the success is consistent with the activism ideas that I have been developing. There are many examples of such successes, some of them are documented in a free software activism article that I wrote several years ago. The implications are pretty far reaching. For more examples, check out this page on GNU-Darwin, or the links page and personal page of this blog. We also should consider the possibility that thinking in similar veins together makes great minds out of us. Of course the internet itself seems pre-designed for that sort of activism. Cheers!

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

Michael L. Love: Merry Christmas Vitacost Community!

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Posted Monday, Dec 28, 2009 9:28 PM by proclus | 0 Comments

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

Hopefully this post will be Merry Christmas to someone. I am surprised by how hard it is to find antifungal nasal spray, as it is likely to address many health complaints. Thus far, I am not impressed with the herbal remedies that purport to do this, although I am willing to listen to any credible evidence. A big problem with some of the remedies is likely that they are not strong enough.

The spray should be strong enough to wipe out all fungal colonies in the nasal cavities, and it should also probably have antibacterial properties to prevent opportunistic infection. This will make the preparation very strong, and it is likely to cause some nasal dryness. Not to worry, because that will be a relief to most sufferers.

As for the health complaints, it is likely a very widespread problem, due to piggy backing on skin, mite, and insect particles, as well as the airborn spores, which are likely to lodge in the nasal cavities. Even overeating could cause the problem, due to nocturnal regurgitation. Personally, I live in an old red brick house in an urban setting near the sea. The old brick draws out moisture from the surrounding soil and air, and is likely furtile ground itself. Such conditions provide ample opportunity for the growth of mold and fungus, and I actually found overnight mushroom heads in my bathroom on a couple of occasions. (BTW, I keep a clean house, and follow the cleanup rules for allergy and asthma.). I have chronic post nasal drip and atopic cough. When I eat food , such as citrus fruits or red onions, with anti-fungal properties, my throat feels better immediately. Unfortunately, I can't stick tangerines up my nose ;-}, and with the post nasal drip, the condition returns. I am waiting for someone to capitalize on this good idea. I gladly will be your trusting guinea pig. Cheers!

Regards,
proclus
http://www.gnu-darwin.org/

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Michael L. Love: Merry Christmas Vitacost Community!

Michael L. Love: Merry Christmas Vitacost Community!

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Posted Friday, Dec 25, 2009 4:07 PM by proclus | 1 Comments

I have knocked together a kind of mockup Vitacost affilliate website. Let me know what you think.

Molecules@GNU-Darwin.org Vitacost Index

There are a few problems. I can make it update periodially with a cron job, so I would need a suggestion regarding the interval. Also, the links in the Health Daily items are broken, probably due to a shortcoming in my email extraction code. I am now tired and abit clueless about how to fix them at this moment. Hopefully I am not stepping on any toes ;-}. Anywho, enjoy! Cheers!

Regards,
proclus
http://www.gnu-darwin.org/

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Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

Michael L. Love: Merry Christmas Vitacost Community!

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Posted Thursday, Dec 24, 2009 6:48 PM by proclus | 0 Comments

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

I am expecting that the following polyphenols will be both highly effective and good free radical scanvengers as well. This is not based on any scientific evaluation, but rather on their widespread use and interest. People are not dummies. Work continues. Here is the list in order of priortity.

resveratrol, lutein, curcumin, quercetin, pycnogenol, rutin, egcg, silymarin, fucoidan, chrysin, diosmin, hesperidin, apigenin, luteolin, naringenin, kaempferol, fisetin, neohesperidin.

There is a wide range represented in the list, and right away I notice that lutein probably does not deserve such high placement in comparison to the others. There are some other possible misplacements, and biochemical insights will provide some refinements of the list. I cut the list very deep in order to include the citrus bioflavanoids, and it probably includes some less important molecules as a result. For example, I mentioned chrysin in a previous post as a possible problem, and rutin probably does not belong above egcg. More to come.

You can probably get a good approximation of this list by checking the Vitacost best sellers. Try searching on antioxidant. It is such a wonderful website, which helped me to compile this list and develop my program. Cheers!

Regards,
proclus
http://www.gnu-darwin.org/

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Posted Wednesday, Dec 23, 2009 12:50 PM by proclus | 2 Comments

I grabbed the following information from my Amazon Seafood Wishlist, because I thought that it deserved more visibiltiy.

The healthful benefits of seafood are widely noted. I am searching for seafood which is low in mercury, high in DHA, and high in astaxanthin, and found that red salmon fills the bill.

DHA is one of the beneficial unsaturated omega 3 fatty acids, which is already widely known for its healthful benefits, and sure to be rising in prominence as well. Caviar is probably one of the best sources of DHA, far and away, and the red variety is also likely rich in astaxanthin, while the black variety is rich in melanin compounds, which are also likely to be healthful. One must be wary however of the food colorings that are used to produce the color in less expensive caviar. Due caution, and more information is needed. I have written an Amazon Guide about this. I am looking for inexpensive caviar that is also low in food coloring. See the wishlist for some examples. There are additional notes about some of the inexpensive caviars in the images section. I am projecting that the simple unprocessed salmon roe will be the best.

Astaxanthin is a carotene-like nutrient that is only available from red fish and certain shell fishes, such as shrimp. I have been told that shrimp are fed to fish in order to deepen their beneficial redness.

Sodium salt is a problem with seafood, but the benefits probably outweigh this problem, especially if you eliminate salt from other parts of your diet. Sodium is a particular problem for caviar, and it is probably unwise to eat unrinsed caviar. Better than rinsing, desalt the caviar. The eggs desalt rapidly because of their small size, and it improves the taste considerably. Don't use too much water though, because it will leach out the DHA. Just add enough water to cover over the eggs, stir gently to break up the clumps, let stand for a few minutes, then drain and rinse. Enjoy your caviar and salmon!

One more thing for Weight Loss Vitacosters, I have found that substituting red salmon and citrus fruits for calorie dense foods has reduced my hunger pangs considerably. Clearly, the salmon can be expected to be very satisfying. I have lost several pounds as a result of this change. I restrict the salmon to a heaping tablespoonful per meal, twice per day, which still provides a substantial amount of the mentioned nutrients.

Regards,
proclus
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

Michael L. Love: Merry Christmas Vitacost Community!

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Posted Tuesday, Dec 22, 2009 1:01 PM by proclus | 1 Comments

I would like te share a little regarding the current direction of my research. The subject may be familiar to most avid users of the Vitacost website. There is a problem with some of the phenolics in that they are
surprisingly not good free radical quenchers, and may in fact spread
free radical damages, if not worsen it. This needs to be better understood.

The importance of this subject becomes evident in consideration of
their binding near the reacting centers of COX enzymes, various
oxidases, and perioxidases. They are thus sequestered near centers of
free radical activity, and their ability to quench that activity is known to be a
crucial component of their functionality.

Chrysin is a flavanoid that is known to have relatively poor free radical quenching
activity, although it is able to bind and inhibit similar targets as
other polyphenols. Due to this fact, chrysin is less effective at
producing some of the key benefits of this class of molecules, and it may actually aggravate the damage caused by enzymes like myeloperoxidase. It is
known that there are other examples of this phenomena, and a survey of
the literature is indicated. Here is my research list. I have thrown in a few "errors", such as tomatoes and indoles for comparison and cross-checking purposes. Images of these molecules are available for your inspection on the Molecules site. Just put them names in the search box. There is much more to say, but perhaps some discussion is in order.

Polyphenol molecules:
Quercetin
EGCG
Silymarin
Resveratrol
Curcumin
Chrysin
Lutein
Kaempferol
Pycnogenol
Rutin
Apigenin
Luteolin
Hesperidin
Naringenin
Naringin
Neohesperidin
fucoidan
diosmin
fisetin
nobiletin

Polyphenol molecule classes:
procyanidins
flavanones
polyphenols
flavones
flavonoids
bioflavanoids
isoflavones
anthocyanidins
cyanidins
chalcones
lignins
tannins
indoles

Polyphenol and antioxidant rich foods:
black cherry
blueberry
cranberry
elderberry
raspberry
goji
pomegranate
acai berry
apple
muscadine
grape
red onion
red cabbage
citrus fruit
tomato
green tea
bilberry
wolfberry
seabuckthorn

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

Michael L. Love: Merry Christmas Vitacost Community!

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Posted Monday, Dec 21, 2009 9:33 PM by proclus | 0 Comments

A Google search on 'molecules activism' produces a page with Linus Pauling near the top. We are obviously in good company. The expired Nobel chemist makes a great example of an activist scientist, one that I have frequently admired. I got a chance to see him speak once, when I was at Phoenix College, and I was no less impressed. In truth, I have tried to emulate him in many ways. His crucial contributions to the world of chemistry and science in general are great enough, but he also drew much needed attention to the problems that society faced in his day. If only we could have more like him.

Also germane is the fact that he is a main reason why many of us are taking vitamin C, something which he continuously advocated. C is now indispensable for its ability to increase the absorbency of polyphenolic molecules, such as resveratrol. For those of us who are attempting to practice calorie restriction, C supplementation is a vital part of the program.    Hats off to Linus Pauling!

Regards,
Michael L. Love Ph.D
Department of Biophysics and Biophysical Chemistry
School of Medicine
Johns Hopkins University
725 N. Wolfe Street
Room 608B WBSB
Baltimore MD 21205-2185

Interoffice Mail: 608B WBSB, SoM
Shipping Dock: 1915 E. Madison St.

office: 410-614-2267
lab:    410-614-3179
fax:    410-502-6910
cell:   443-824-3451
http://www.gnu-darwin.org/

The blog

Michael L. Love: Community blog to rss extraction code

Michael L. Love: more parsley info, anti-diarrhea and other matters

Michael L. Love: polyphenols and stable free radicals

Michael L. Love: some bio info, blog links, plus some molecules site news

Michael L. Love: USDA Database for the Flavonoid Content

Michael L. Love: recipe; flax oil, tyrosol lignans update

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Posted Saturday, Dec 19, 2009 8:25 PM by proclus | 2 Comments

Michael L. Love: Molecules Activism on Vitacost: Thai Black Rice update

My program is under constant development, and sites like Vitacost and Molecules are excellent tools for program development. I have included a few suggestions in my product recommendations section. Here is a link to my personal page, where you will find my supplement recommendations and product links.

http://community.vitacost.com/Templates/MyPage.aspx?UserID=4424

I am a happy but discontent person, and I always looking for ways to improve. I also eager to hear any suggestions and even criticism. Please feel free to write in.

Regards,
proclus
http://www.gnu-darwin.org/

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Michael L. Love: Merry Christmas Vitacost Community!